Publications by authors named "P A McCullough"
Objective: Hydroxychloroquine paired with Azithromycin, Vitamin C, Vitamin D, and Zinc (HAZDPac), was used as a multidrug therapy method to treat COVID-19 illness and superimposed secondary bacterial pneumonia. Concerns have been raised though about such combinations regarding cardiac QTc interval prolongation and risks of arrhythmias, which we set out to address in this study.
Design: We evaluated cardiac safety in a Phase II Double-Blind Randomized Placebo-Controlled Trial of Combination Therapy to Treat COVID-19 Infections study, conducted by ProgenaBiome.
Article Synopsis
- - Lutein is a powerful antioxidant and anti-inflammatory compound found in certain foods that can improve eye health, support heart and metabolic function, and protect against conditions like neurodegenerative diseases and chronic illnesses.
- - It plays a role in mitigating oxidative and nitrosative stress linked to long COVID and mRNA vaccine-related injuries, potentially reducing inflammation caused by the SARS-CoV-2 spike protein.
- - A diet rich in lutein, particularly when combined with Extra Virgin Olive Oil (EVOO) for better absorption, may be beneficial for recovery in post-COVID situations due to its ability to suppress harmful molecular pathways.
Article Synopsis
- In May 2023, the FDA approved a Pfizer-sponsored bivalent RSV vaccine (AbrysvoTM) for use in pregnant women to prevent RSV infections in newborns, following safety concerns that halted GSK trials in 2022.
- A comprehensive evaluation of randomized controlled trials (RCTs) showed several maternal side effects were more common with the RSVpreF vaccine, including local reactions, fatigue, and joint pain.
- Despite increased side effects, the vaccine significantly reduced cases of RSV-related lower respiratory tract disease and hospitalizations, but there was a notable rise in the risk of preterm delivery associated with its use.
Article Synopsis
- The development of mRNA vaccines like Pfizer-BioNTech and Moderna in 2020 overcame challenges related to mRNA instability and immunity, marking a key advancement in vaccine technology.
- The paper discusses improvements in mRNA stability and efficiency through nucleoside modifications and design elements, while raising concerns about the widespread distribution of the vaccines leading to potential inflammatory responses and safety issues.
- It suggests exploring small interfering RNA (siRNA) and ribonuclease targeting chimeras (RIBOTACs) as methods to target and degrade excess vaccine mRNA, which could help prevent harmful spike protein production and reduce side effects.
Background Surgical site infection in colon surgery is associated with significant cost and increased length of hospital stay. Recently, there has been interest in the use of pulsed lavage to reduce the risk of surgical site infection in contaminated wounds. Although increasingly used and gaining popularity, its effectiveness in elective colorectal surgery has been poorly documented.
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