Publications by authors named "P A McClean"

Missing Alzheimer's disease (AD) data is prevalent and poses significant challenges for AD diagnosis. Previous studies have explored various data imputation approaches on AD data, but the systematic evaluation of deep learning algorithms for imputing heterogeneous and comprehensive AD data is limited. This study investigates the efficacy of denoising autoencoder-based imputation of missing key features of heterogeneous data that comprised tau-PET, MRI, cognitive and functional assessments, genotype, sociodemographic, and medical history.

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White mold, caused by the fungus Sclerotinia sclerotiorum (Lib.) de Bary, is a devastating disease affecting common bean (Phaseolus vulgaris L.) production worldwide.

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Article Synopsis
  • Cellular senescence refers to the permanent halt of cell growth caused by factors like genetic mutations or damage, and it's linked to aging and diseases like diabetes and heart issues.
  • The study aimed to identify specific senescence biomarkers in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) using OLINK proteomics.
  • The proteins CKAP4 and PTX3 were found to be significantly elevated in AKI and CKD patients, suggesting they could serve as important indicators for kidney disease progression.
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Flavonoids are secondary metabolites associated with plant seed coat and flower color. These compounds provide health benefits to humans as anti-inflammatory and antioxidant compounds. The expression of the late biosynthetic genes in the flavonoid pathway is controlled by a ternary MBW protein complex consisting of interfacing MYB, beta-helix-loop-helix (bHLH), and WD40 Repeat (WDR) proteins.

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