How did investigations into spontaneous human combustion influence alcohol medicine? An examination of the medical and literary discussions that brought the two together.

Background And Aims: The presence of sections or chapters on spontaneous human combustion in more than half of the key texts in English on the action of alcohol on the body and mind in the first half of the nineteenth century demonstrates the seriousness with which it was considered. We aimed to chart discussions about the links between spontaneous human combustion and spirit drinking in medical texts and representations in fiction through three key chronological periods from 1804 to 1900.

Methods: A contextual analysis using eighteenth- and nineteenth-century historical, literary and medical sources to chart and reflect on public and medical discourses.

Syntheses, Structures and Reactivity of Metal Complexes of Trindane, Trindene, Truxene, Decacyclene and Related Ring Systems: Manifestations of Three-Fold Symmetry.

The triple condensation of cyclopentanone or indanone to trindane (CH) or truxene (CH), respectively, provides convenient access to molecular skeletons on which major fragments of the prototypical fullerene C can be assembled. In particular, early approaches (both organic and organometallic) towards sumanene, as well as the final successful synthesis, are described. Organometallic derivatives of trindane have been prepared in which Cr(CO), Mo(CO), [Mn(CO)] or [(CH)Fe(CO)] are η-bonded to the central arene ring.

Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer.

Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target the molecular alterations driving tumor progression are needed. Annexin A1 is an abundant multi-functional Ca binding and membrane-associated protein. Reported roles of Annexin A1 in breast cancer progression and metastasis are contradictory.