Reinforced Collaborative-Competitive Representation for Biomedical Image Recognition.

Artificial intelligence technology has demonstrated remarkable diagnostic efficacy in modern biomedical image analysis. However, the practical application of artificial intelligence is significantly limited by the presence of similar pathologies among different diseases and the diversity of pathologies within the same disease. To address this issue, this paper proposes a reinforced collaborative-competitive representation classification (RCCRC) method.

Transthyretin Cardiac Amyloidosis: Current and Emerging Therapies.

Purpose Of Review: In this article, we describe current and newer TTR stabilizers, TTR silencers which include small interfering RNA agents (siRNA), antisense oligonucleotides (ASO) and CRISPR-Cas9 gene editing, and TTR depleters, which investigates the use of monoclonal antibodies to remove amyloid fibril deposits for patients with advanced disease.

Recent Findings: Once thought to be a rare and fatal condition, increased recognition, improved non-invasive diagnostic tools, and the explosive development of novel therapies, has transformed the landscape of transthyretin amyloid cardiomyopathy (ATTR-CM). Advances in cardiac imaging with respect to echocardiography, cardiac magnetic resonance imaging (CMR), and radionuclide bone scintigraphy has increased the diagnosis of ATTR-CM over the last twenty years.

Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia.

Immune and metabolic factors play an important role in the onset and development of insomnia. This study aimed to investigate the causal relationship between insomnia and immune cells and metabolites. Data for 731 immune cell phenotypes, 1400 metabolites, and insomnia in this study were obtained from the GWAS open-access database.

Does Nonsteroidal Anti-inflammatory Drug Use Modify All-Cause and Cause-Specific Mortality Associated with PM and Its Components? A Nationally Representative Cohort Study (2007-2017).

Several studies reported that nonsteroidal anti-inflammatory drug (NSAID) use could alleviate subclinical effects of short-term exposure to fine particulate matter (PM). However, whether chronic NSAID use could mitigate the long-term effects of PM and its components on population mortality has been unknown. Based on a national representative survey of 47,086 adults (2007-2010) with follow-up information on the primary cause of death (until 2017), we investigated the long-term associations of PM and its major components, including black carbon (BC), ammonium (NH ), nitrate (NO ), organic matter (OM), and sulfate (SO ), with all-cause and cause-specific mortality using the Cox proportional hazards model.