Publications by authors named "P A Lalitha"
Article Synopsis
- Microbial resistance to drugs and antibiotics is a growing issue, prompting researchers to explore new materials like borophene as potential solutions.
- Boron nanosheets are synthesized from MgB2 by selectively removing magnesium atoms, resulting in structures that are characterized using advanced techniques.
- The study demonstrates the antibacterial efficacy of boron nanosheets against clinical strains of bacteria, revealing significant zones of inhibition and providing insights into their potential medical applications.
Association between in vitro susceptibility and clinical outcomes in fungal keratitis.
J Ophthalmic Inflamm Infect
September 2024
Purpose: The purpose of this study was to assess the association between antifungal susceptibility as measured by minimum inhibitory concentration (MIC) and clinical outcomes in fungal keratitis.
Methods: This pre-specified secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) involved patients with filamentous fungal keratitis presenting to Aravind Eye Hospitals in South India. Antifungal susceptibility testing for natamycin and voriconazole was performed on all samples with positive fungal culture results according to Clinical and Laboratory Standards Institute Guidelines.
Purpose: The Steroids and Cross-linking for Ulcer Treatment Trial is an NIH-funded international, randomized, double-masked, sham and placebo-controlled clinical trial to determine the benefit of adjunctive corneal cross-linking with riboflavin and/or topical difluprednate in addition to topical antibiotic drops for treatment of smear-positive bacterial ulcers. The purpose of this study was to explore the baseline characteristics for infection of patients enrolled, and the ocular comorbidities of patients screened for inclusion.
Methods: Of the 2005 patients with smear-positive bacterial ulcers screened, 280 patients were enrolled.
Background: Infectious keratitis secondary to fungus or acanthamoeba often has a poor outcome despite receiving the best available medical therapy. In vitro rose bengal photodynamic therapy (RB-PDT) appears to be effective against fungal and acanthamoeba isolates (Atalay HT et al., Curr Eye Res 43:1322-5, 2018, Arboleda A et al.
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- The study aimed to explore the relationship between weather variables and various pathogens linked to infectious conjunctivitis globally.
- Researchers analyzed data from 498 cases across 8 countries, correlating pathogen types with weather data, particularly looking at temperature, precipitation, and humidity.
- Findings indicated that higher humidity and precipitation increased the likelihood of RNA virus and fungal infections while decreasing the odds of DNA virus and bacterial infections, highlighting the complex influence of weather on conjunctivitis-related pathogens.