Publications by authors named "P A LITTLE"
Background: This systematic review evaluates the effect of audit and feedback (A&F) interventions targeting antibiotic prescribing in primary care and examines factors that may explain the variation in effectiveness.
Methods: Randomized controlled trials (RCTs) involving A&F interventions targeting antibiotic prescribing in primary care were included in the systematic review. Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and ClinicalTrials.
Antibiotic-perturbed microbiota and the role of probiotics.
Nat Rev Gastroenterol Hepatol
December 2024
Article Synopsis
- * Clinical studies show probiotics might help reduce side effects like diarrhea from Clostridioides difficile, yet there's no direct evidence connecting these outcomes to microbiota protection.
- * The review discusses the complexities of studying microbiota restoration, including the challenges of defining a "normal" microbiota, varying measurement methods, and individual differences, while suggesting future research directions.
Introduction: Evaluating the safety and acceptability of reusing catheters for intermittent catheterisation (IC) is one of the top 10 continence research priorities identified by the UK James Lind Alliance Priority Setting Partnership in 2008. There are an estimated 50 000 IC users in England and this number is rising. Globally, both single-use catheters (thrown away after use) and multi-use/reusable ones (cleaned between uses) are used.
View Article and Find Full Text PDFObjectives: Do weekly prophylactic saline or acidic catheter washouts in addition to standard long-term catheter (LTC) care improve the outcomes of adults with LTC compared with standard LTC care only.
Design: Three-arm superiority open-label randomised controlled trial.
Setting: UK community-based study.
A complex intervention to reduce antibiotic prescribing in rural China: a cluster randomised controlled trial.
Lancet Reg Health West Pac
December 2024
Background: Excessive use of antibiotics is a widespread problem. We aim to evaluate the efficacy of a multifaceted intervention for reducing antibiotic use in patients with respiratory tract infections (RTIs).
Methods: In this two-arm cluster randomized controlled trial, we enrolled patients aged 18+ with symptomatic RTIs at 40 township health centers (THCs) selected from 10 counties in Anhui, China.