Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy.

Background: Epilepsy affects millions of people worldwide, yet we still lack a successful treatment for all epileptic patients. Most of the available drugs modulate neuronal activity. Astrocytes, the most abundant cells in the brain, may constitute alternative drug targets.

The Effect of the Operation of Downhole Equipment on the Processes of Corrosive Wear (by the Example Inflow Control Devices of Nozzle Type).

Existing approaches to assessing the reliability and safe operation of downhole equipment provide for assessing only the direct impact of erosion and corrosion processes on the degradation of the material. At the same time, the influence of downhole equipment operating modes on the intensity of corrosion and erosion processes is not evaluated. The necessity of using inflow control devices is shown.

MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity.

The extracellular matrix (ECM) has been identified as a critical factor affecting synaptic function. It forms a functional scaffold that provides both the structural support and the reservoir of signaling molecules necessary for communication between cellular constituents of the central nervous system (CNS). Among numerous ECM components and modifiers that play a role in the physiological and pathological synaptic plasticity, matrix metalloproteinase 9 (MMP-9) has recently emerged as a key molecule.