Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity.

Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity.

[SURGICAL TREATMENT OF PATIENTS FOR METACHRONOUS METASTASES OF PULMONARY OSTEOSARCOMA. CLINICAL PROGNOSTIC FACTORS].

The impact of surgical method on results of complex treatment in patients, suffering the osteosarcoma metachronous pulmonary metastases, was studied. The survival indices in 93 patients were analyzed, of them in 71, suffering osteosarcoma - with complex treatment, including surgical intervention of complete excision of all metastases (three-years survival – 34.2%), and in 21 – complex treatment with palliative radiation therapy (three-year survival 3.

[TARTRAT-RESISTANT ACID PHOSPHATASE AS BONE'S RESORBTION MARKER IN PATIENTS WITH BONE METASTASES].

Determination of serum markets of bone resorption in patients, with renal cancer after radical surgery can improve the accuracy of early diagnosis of bone metastases, assess the extent of metastatic bone lesions, and monitoring of bisphosphonates treatment. These data suggest promising activity for tartrat-resistant acid phosphatase (TRAP-5b) of early detection of bone metastasis.