Publications by authors named "P A Kempster"
Introduction: Abnormal reactive saccade, with reduced saccadic gain, impaired smooth pursuit, and unwarranted reactions are clinically used to assess people with Parkinson's disease (PwPD). However, there are inconsistent findings related to other saccade parameters such as latency and transition times. This study aimed to identify differences in the reflexive saccade parameters of early stage PwPD and aged-matched control (AMC).
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- This study systematically reviewed and analyzed data on motor progression in Parkinson's disease (PD), emphasizing that current tools for assessing treatment effects are heavily influenced by dopaminergic therapies.
- It found that untreated PD patients showed a significantly higher motor progression rate of 4.5% per year compared to only 1.6% for those receiving dopaminergic drugs, indicating the importance of considering treatment status in studies.
- The research suggests that long-term measurements of motor progression can still be effective even after starting dopaminergic medications, but calls for careful study designs to reduce confounding factors associated with symptom treatment.
Background: Several validated clinical scales measure the severity of essential tremor (ET). Their assessments are subjective and can depend on familiarity and training with scoring systems.
Method: We propose a multi-modal sensing using a wearable inertial measurement unit for estimating scores on the Fahn-Tolosa-Marin tremor rating scale (FTM) and determine the classification accuracy within the tremor type.
Background: Autoimmune encephalitis (AE) is an increasingly recognized neuroinflammatory disease entity in which early detection and treatment leads to the best clinical outcomes. Movement disorders occur in AE but their characteristics are not well defined.
Objectives: To identify the frequency, classification, and prognostic significance of movement disorders in AE.
Computerized analysis of speech and voice for Parkinson's disease: A systematic review.
Comput Methods Programs Biomed
November 2022
Background And Objective: Speech impairment is an early symptom of Parkinson's disease (PD). This study has summarized the literature related to speech and voice in detecting PD and assessing its severity.
Methods: A systematic review of the literature from 2010 to 2021 to investigate analysis methods and signal features.