[SGLT2 inhibitors : promises, but for whom ?].

In type 2 diabetes, the launch of gliflozins (or SGLT2i), like each new therapeutic class, is generating a great deal of hope and is being heavily marketed. The pivotal studies show a beneficial effect on the risk of hospitalization for heart failure and, to a lesser extent, on the decline in renal function. The impact on physiological factors (weight, glycated hemoglobin, blood pressure) is modest, and the side-effect profile is relatively heavy, particularly in the elderly (frequent urogenital infections, ketoacidosis, etc.

Clinical and microbiological determinants of severe and fatal outcomes in patients infected with Enterobacteriaceae producing extended-spectrum β-lactamase.

Although extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have become a worldwide public health concern, little is known regarding the clinical course of colonized or infected individuals. Our objective was to characterize the determinants of fatal outcomes related to ESBL-producing microorganisms at a large hospital in Paris, France. In 2012-2013, all consecutive patients with clinical samples testing positive for ESBL-producing Enterobacteriaceae at Saint-Antoine Hospital were identified.

An observational study of adult admissions to a medical ICU due to adverse drug events.

Background: The objectives of the study were to estimate the incidence of intensive care unit (ICU) admissions due to adverse drug events (ADEs), to assess preventability, severity and costs of the corresponding ADE and to determine the leading causes of preventable ADEs.

Methods: An observational study was conducted in a medical ICU of a teaching hospital from February 2013 to February 2014.

Results: A total of 743 consecutive admissions were included, and they involved 701 different patients.

Clostridium difficile flagella predominantly activate TLR5-linked NF-κB pathway in epithelial cells.

Clostridium difficile has become the most common enteropathogen responsible for intestinal nosocomial post-antibiotic infections. This has coincided with the appearance of serious cases related to the emergence of hypervirulent strains. The toxins are the main virulence factors and elicit an inflammatory response during C.