Clinical and Carotid Plaque Features in Symptomatic and Asymptomatic Ischemic Stroke.

Ischemic stroke (IS), a cerebrovascular condition, is commonly detected by evaluating carotid intima-media (CIA) stenosis. Symptomatic CIA stenosis carries a high risk (up to 32%) of another ischemic event within 12 weeks, while asymptomatic CIA stenosis has an annual risk ranging from 1% to 2%. Therefore, this study aims to explore the diagnostic value of clinical features and carotid plaque characteristics in both symptomatic and asymptomatic IS.

Gestational trophoblastic disease: STR genotyping for precision diagnosis.

Introduction: Gestational trophoblastic disease (GTD) encompasses a constellation of rare to common gynecologic conditions stemming from aberrant gestations with distinct genetic backgrounds and variable degrees of trophoblast proliferation of either neoplastic or non-neoplastic nature. GTD is categorized into hydatidiform moles and gestational trophoblastic neoplasms, and their clinical outcomes vary widely across different subtypes. Prompt and accurate diagnosis plays a pivotal role in the effective management and prognostication of patients.

Uterine teratoma and the role of short-tandem repeat genotyping in understanding origins.

Background: Uterine teratomas are a rare entity with a debated origin. Given its rarity and limitations of diagnostic imaging, diagnosis is typically determined pathologically following surgical resection based on the presence of tissue derived from all germ cell layers. Unlike its ovarian counterpart, the developmental origins are poorly understood; however, recently introduced molecular testing has revolutionized our understanding of these rare tumors.

Development and validation of a prognostic nomogram based on the hub genes of patients with hypertensive intracerebral hemorrhage.

Objective: Hypertensive intracerebral hemorrhage (HICH) is frequently associated with high disability, high mortality, and poor prognosis. The present study aimed to identify genes associated with HICH to construct prognostic models to improve accuracy in predicting HICH prognosis.

Methods: Hub genes were identified by screening out differentially expressed genes from data in the Gene Expression Omnibus database and conducting weighted gene co-expression network analysis.

DNA ligase III mediates deoxynivalenol exposure-induced DNA damage in intestinal epithelial cells by regulating oxidative stress and interaction with PCNA.

Deoxynivalenol (DON) is a widely distributed mycotoxin that is severely cytotoxic and genotoxic to animals and humans. The gut is the initial site of DON exposure and absorption, which can cause severe intestinal damage. However, the underlying mechanisms and effective therapeutic approaches remain unknown.