Publications by authors named "P A Holmans"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFMeta-Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross-Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross-Study Heterogeneity.
Am J Med Genet B Neuropsychiatr Genet
December 2024
The comprehensive genome-wide nature of transcriptome studies in Alzheimer's disease (AD) should provide a reliable description of disease molecular states. However, the genes and molecular systems nominated by transcriptomic studies do not always overlap. Even when results do align, it is not clear if those observations represent true consensus across many studies.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how positive, negative, and disorganized psychotic symptom dimensions relate to different clinical and developmental variables, addressing inconsistencies in definition and prior research.
- Results showed that higher symptom scores were linked to poor social adjustment, earlier onset of symptoms, and specific demographic factors, such as ethnicity and gender.
- The findings also suggested a significant familial influence on disorganized symptoms, highlighting the connections between these symptoms and lower premorbid IQ, especially within monozygotic twin pairs.
Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia.
Biol Psychiatry Glob Open Sci
September 2024
Background: The prefrontal cortex (PFC) has been strongly implicated in the pathophysiology of schizophrenia. Here, we combined high-resolution single-nuclei RNA sequencing data from the human PFC with large-scale genomic data for schizophrenia to identify constituent cell populations likely to mediate genetic liability to the disorder.
Methods: Gene expression specificity values were calculated from a single-nuclei RNA sequencing dataset comprising 84 cell populations from the human PFC, spanning gestation to adulthood.