Publications by authors named "P A Healy"
Aims: Our investigation aimed to assess the dose rationale of tramadol in paediatric patients considering the effect of CYP2D6/OCT1 polymorphisms on systemic exposure. Recommendations were made for the oral dose of tramadol to be used in a prospective study in children (3 months to < 18 years old) with chronic pain.
Methods: Intravenous pharmacokinetic and genotype data from neonatal patients (n = 46) were available for this analysis.
Article Synopsis
- Neonatal encephalopathy (NE) is a serious condition impacting newborns, where therapeutic hypothermia is the standard treatment, yet many still face long-term issues; the paper aims to create a Core Outcome Set (COS) for consistent reporting in studies.* -
- A systematic review of 116 papers identified 386 reported outcomes from NE studies, categorized into 18 domains, highlighting a lack of uniformity as no single outcome was universally reported across studies.* -
- The findings emphasize the need for standardized outcome measures, including family input, to improve the comparison of treatments and enhance research on NE.*
Background: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE) makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable researchers to measure and report the same outcomes in future trials. This would minimise waste, ensure relevant outcomes are measured and enable evidence synthesis.
View Article and Find Full Text PDFBackground: Needle phobia, which affects 19% of children aged 4 to 6 years, prevents many children from receiving necessary or preventive medical treatments. Digital interventions have been made to target needle phobia but currently rely on distraction rather than evidence-based exposure.
Objective: We designed and evaluated a serious exposure-based mobile game called Dr.