Publications by authors named "P A Goldberg"

Article Synopsis
  • - The study explores variations in the age at cancer diagnosis among Lynch syndrome patients, focusing on how genetic polymorphisms influence this variability, particularly in South Africans with specific germline pathogenic variants.
  • - An analysis was conducted on 359 Lynch syndrome variant heterozygotes using advanced genetic testing methods to identify associations between genetic polymorphisms and the age at which cancer was diagnosed.
  • - Results showed that certain genotypes increased the likelihood of younger cancer diagnosis, while others provided protective effects, suggesting that a mix of risk and protective genes plays a significant role in cancer onset age among Lynch syndrome patients.
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Purpose: To examine anthropometric predictors of BMI 30 years after the onset of adolescent AN.

Methods: A group of 51 individuals with adolescent-onset AN were identified in Sweden in 1985. Anthropometric data have been collected from birth records and school nurse charts.

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Lynch syndrome (LS) is an inherited cancer predisposition disorder associated with an elevated risk of developing various solid cancers, but mostly colorectal cancer (CRC). Despite having the same germline pathogenic variant (PV) in one of the mis-match repair genes or the gene, Lynch syndrome variant heterozygotes (LSVH) exhibit a remarkable phenotypic variability in the risk of developing cancer. The role of human leukocyte antigen (HLA) in modifying cancer development risk prompted our hypothesis into whether HLA variations act as potential genetic modifiers influencing the age at cancer diagnosis in LSVH.

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Biologically engineered nanomaterials give rise to unique and intriguing properties, which are not available in nature. The full-realization of such has been hindered by the lack of robust and straightforward techniques to produce the required architectures. Here a new bottomup bionano-engineering route is developed to construct nanomaterials using a guided assembly of collagen building blocks, establishing a lithographic process for three-dimensional collagen-based hierarchical micronano-architectures.

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