Publications by authors named "P A Gevenois"
Rationale: Endoscopic lung volume reduction improves lung function, quality of life and exercise capacity in severe emphysema patients. However, its effect on the diaphragm function is not well understood. We hypothesised that endoscopic lung volume reduction increases its strength by modifying its shape.
View Article and Find Full Text PDFThe diaphragm is the main inspiratory muscle and separates the thorax and the abdomen. In COPD, the evaluation of the diaphragm shape is clinically important, especially in the case of hyperinflation. However, delineating the diaphragm remains a challenge as it cannot be seen entirely on CT scans.
View Article and Find Full Text PDFMembers of the Fleischner Society have compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984, 1996, and 2008, respectively. The impetus to update the previous version arose from multiple considerations. These include an awareness that new terms and concepts have emerged, others have become obsolete, and the usage of some terms has either changed or become inconsistent to a degree that warranted a new definition.
View Article and Find Full Text PDFBackground: Our aims were to explore the feasibility, safety, and efficacy of peroperative transbronchial lung cryobiopsy (TBLC) guided by electromagnetic navigation bronchoscopy (ENB) and ENB-guided methylene blue marking of presumably non-palpable pulmonary nodules, and to assess its impact on video-assisted thoracoscopic surgery (VATS) and postoperative lung function.
Methods: This approach was applied to 16 consecutive patients (Group A, mean age 64 years) who were compared retrospectively to a historical group of 49 patients (Group B, mean age 62 years) with similar nodules resected without guidance. The usefulness of dye marking was graded.
Article Synopsis
- IL-13 is a cytokine primarily produced by Th2 cells, involved in allergic responses, inflammation, and fibrosis, making it a target for therapeutic research, though human clinical trials with conventional antibodies targeting IL-13 have mainly been unsuccessful.
- Nanobodies, derived from camel antibodies, show promise due to their small size and ability to be engineered for targeted therapies, particularly in local administration.
- This study successfully developed 38 nanobodies, with some showing good affinity, and through creating multimeric constructs, researchers significantly improved their effectiveness against IL-13 while maintaining specificity.