Publications by authors named "P A E Sillevis Smitt"
Article Synopsis
- The study aimed to evaluate the prevalence of neuronal antibodies in patients diagnosed with neurodegenerative dementia, as these can mimic conditions like autoimmune encephalitis (AIE) and potentially respond to immunotherapy.
- In a cohort of 920 dementia patients, only 0.8% were found to have neuronal antibodies, along with a variety of atypical symptoms that distinguished them from typical neurodegenerative cases.
- None of the patients exhibited significant MRI abnormalities associated with AIE, and only one patient showed an atypical change in cerebrospinal fluid, emphasizing the complexity of diagnosing these conditions.
Background And Objectives: To describe the clinical features of anti-NMDAR encephalitis, emphasizing on late-onset patients and antibody test characteristics in serum and CSF.
Methods: Nationwide observational Dutch cohort study, in patients diagnosed with anti-NMDAR encephalitis between 2007 and 2019.
Results: One hundred twenty-six patients with anti-NMDAR encephalitis were included with a median age of 24 years (range 1-86 years).
The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specific gene alterations.
View Article and Find Full Text PDFAlthough many patients are cured from prostate cancer (PCa) by surgery only, there are still patients who will experience rising prostate-specific antigen (PSA) levels after surgery, a condition known as biochemical recurrence (BCR). Novel protein prognostic markers in PCa tissue might enable finding better treatment for those patients experiencing BCR with a high chance of metastasis. In this study, we aimed to identify altered proteins in prostate cancer tissue, and to evaluate their potential role as prognostic markers.
View Article and Find Full Text PDFMultiple sclerosis (MScl) frequently is remitted during the third trimester of pregnancy but exacerbated in the first postpartum period. In this context, we investigated protein identification, its abundance, and its change in urine related to these two periods. Using mass spectrometry (LTQ Orbitrap), we identified 1699 tryptic peptides (related to 402 proteins) in urine from 31 MScl and 8 control at these two periods.
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