A mechanistic model for determining factors that influence inorganic nitrogen fate in corn cultivation.

Conventional practices for inorganic nitrogen fertilizer are highly inefficient leading to excess nitrogen in the environment. Excess environmental nitrogen induces ecological (, hypoxia, eutrophication) and public health (, nitrate contaminated drinking water) consequences, motivating adoption of management strategies to improve fertilizer use efficiency. Yet, how to limit the environmental impacts from inorganic nitrogen fertilizer while maintaining crop yields is a persistent challenge.

Targeted exonic sequencing identifies novel variants in a cerebral small vessel disease cohort.

Background And Aims: Cerebral small vessel diseases (CSVDs) are a set of conditions that affect the small blood vessels in the brain and can cause severe neurological pathologies such as stroke and vascular dementia. The most common monogenic CSVD is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) which is caused by mutations in NOTCH3. However, only 15-20% of CADASIL cases referred for genetic testing have pathogenic mutations in NOTCH3.

Telomerase-Mediated Anti-Ageing Interventions.

The ageing process involves a gradual decline of chromosome integrity throughout an organism's lifespan. Telomeres are protective DNA-protein complexes that cap the ends of linear chromosomes in eukaryotic organisms. Telomeric DNA consists of long stretches of short "TTAGGG" repeats that are conserved across most eukaryotes including humans.

NHS action on social and economic development in England: Vague national policy expectations.

Under recent reforms to the National Health Service (NHS) in England, NHS organizations have been given new objectives to contribute to social and economic development. Health systems in other high-income countries are pursuing related approaches. This paper analyses national policy documents to understand the framing of the NHS's new policy priorities on social and economic development.