Publications by authors named "P A Doris"
Article Synopsis
- A new reference genome assembly for the laboratory rat, named GRCr8, has been developed and is recognized by the Genome Reference Consortium.
- The assembly utilized advanced sequencing techniques (40× PacBio HiFi sequencing) and includes chromosome-level data, with 98.7% of sequences assigned to chromosomes, showing overall increases in chromosome sizes and notable expansions on Chromosomes 3, 11, 12, and Chr Y.
- The new assembly enhances genome quality by incorporating over 1100 new protein-coding genes and includes previously unannotated genes and centromeric sequences, supported by concurrent PacBio Iso-Seq data from multiple rat tissues.
Article Synopsis
- * New genetic studies have created a better version of the rat's DNA map, called GRCr8, which is more accurate and includes new information.
- * As technology improves, researchers are now able to make more detailed DNA maps of different rat breeds, helping to unlock even more secrets about their genetics.
The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor. Gene annotations are now more complete, improving the mapping precision of genomic, transcriptomic, and proteomics datasets.
View Article and Find Full Text PDFDuring development of the spontaneously hypertensive rat (SHR), several distinct but closely related lines were generated. Most lines are resistant to hypertensive renal disease. However, the SHR-A3 line (stroke-prone SHR) experiences end-organ injury (EOI) and provides a model of injury susceptibility that can be used to uncover genetic causation.
View Article and Find Full Text PDFThe seventh iteration of the reference genome assembly for -mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared to its predecessor. Gene annotations are now more complete, significantly improving the mapping precision of genomic, transcriptomic, and proteomics data sets.
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