Publications by authors named "P A Dargaville"
Neonatal apneas and hypopneas present a serious risk for healthy infant development. Treating these adverse events requires frequent manual stimulation by skilled personnel, which can lead to alarm fatigue. This study aims to develop and validate an interpretable model that can predict apneas and hypopneas.
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- Bronchopulmonary dysplasia (BPD) is a serious condition affecting extremely preterm infants, and while systemic corticosteroids can help, they come with risks; inhaled corticosteroids may provide a safer alternative.
- The study aimed to assess the effectiveness of administering budesonide, an inhaled corticosteroid, alongside surfactant in improving survival rates without BPD among extremely preterm infants.
- Conducted across 21 neonatal units in four countries, the trial involved 1,059 infants and found that 25.6% of those receiving budesonide plus surfactant survived without BPD, compared to 22.6% in the surfactant-only group.
Premedication for less invasive surfactant administration: a narrative review.
Arch Dis Child Fetal Neonatal Ed
October 2024
Article Synopsis
- - Less invasive surfactant administration (LISA) is gaining traction for treating respiratory distress syndrome in preterm infants who are breathing on their own.
- - The best ways to manage pain and discomfort during LISA, whether through medication or other methods, are still uncertain, leading to inconsistent practices among healthcare providers.
- - This article aims to highlight the current understanding of LISA and identify where more research is needed regarding premedication options before the procedure.
Background: Less invasive surfactant administration (LISA) has become the preferred method of surfactant administration for spontaneously breathing babies on continuous positive airway pressure (CPAP).
Summary: The development of LISA followed the need to combine CPAP and surfactant replacement as mainstay treatment options for respiratory distress syndrome, thereby avoided exposure to positive pressure ventilation.
Key Messages: This review summarises the current knowns and unknowns of LISA including the physiological concept, its relevance for short-term and long-term outcomes and the challenges for practical implementation of LISA as part of a less invasive respiratory care bundle.