Publications by authors named "P A Cross"
A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies in patients with active Crohn's disease.
Jeremy Sanderson Jeremy Aboagye Rebecca Makinson Katerina Rapi Samuel Provstgaard-Morys Paul Ian Cross
EBioMedicine
March 2025
Background: Crohn's Disease (CD) is a chronic, debilitating condition hypothesised to be associated with Mycobacterium avium ssp paratuberculosis (MAP) infection. It is the causative pathogen of the granulomatous inflammatory enteritis in ruminants, Johne's Disease. A developing treatment approach is utilising heterologous prime-boost viral vectored vaccines.
View Article and Find Full Text PDFIntroduction: The relationship between 24-h movement behaviours (i.e. sleep, sedentary behaviour and physical activity) and adiposity in preschoolers remains unclear.
View Article and Find Full Text PDFEffective, practical options for managing disease in wildlife populations are limited, especially after diseases become established. Removal strategies (e.g.
View Article and Find Full Text PDFArticle Synopsis
- The prevalence of physical activity, sedentary behavior, and sleep among 3- and 4-year-old children globally is unclear, highlighting the need for consistent data.
- This study analyzed data from 14 cross-sectional studies across 33 countries to determine how many children met WHO guidelines for physical activity, screen time, and sleep over recent years.
- Only 14.3% of the 7017 children studied met all the guidelines, with no significant differences found between countries with varying income levels regarding adherence to these health recommendations.
Article Synopsis
- A cross-sectional study involving 797 children aged 3-4 from diverse countries found that only about 30.9% met the global guideline of 180 minutes of total physical activity (TPA) daily, as indicated by a mean daily step count of 10,295 steps.
- The study revealed that boys, younger children, urban residents, and those from higher-income countries were less likely to meet the TPA guideline, highlighting significant sociodemographic differences in physical activity levels.
- These results emphasize the importance of monitoring TPA in early childhood and call for potential interventions to enhance physical activity and overall health among young children worldwide.