Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility.

Heritable fragile bone disorders (FBDs), ranging from multifactorial to rare monogenic conditions, are characterized by an elevated fracture risk. Validating causative genes and understanding their mechanisms remain challenging. We assessed a semi-high throughput zebrafish screening platform for rapid in vivo functional testing of candidate FBD genes.

"Assessing the Effect of a Mobile Application on Cancer Risk Health Literacy: A Cross-Sectional Study Design".

Background: The "Cancer Risk Calculator" mobile application aims to inform patients about their personal risks of cancer and their risk factors influencingsaid risks. The present analysis examines the responses to a questionnaire submitted by oncology patients treated with radiotherapy or their family members.

Objective: The primary objective was to determine the effectof the app on the user's awareness and potential habit changes related to cancer risk.

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model.

Rare monogenic disorders often exhibit significant phenotypic variability among individuals sharing identical genetic mutations. Bruck syndrome (BS), a prime example, is characterized by bone fragility and congenital contractures, although with a pronounced variability among family members. BS arises from recessive biallelic mutations in FKBP10 or PLOD2.

[Health is a serious matter : so let's play ! Part 2 : an overview of «serious gaming» in mental health].

In a first article we highlighted the importance of serious gaming in physical medicine and in rehabilitation. In this second article on the same topic, we discuss the potential impact of serious gaming in the field of mental health. The technical aspects, advantages and disadvantages, limits and pitfalls are rapidly overviewed in different areas such as addiction, anxiety, autism, depression, schizophrenia, attention disorders, post-traumatic stress syndrome, obsessive compulsive disorders and memory disorders.