Publications by authors named "P A Cotter"
Aims: Gestational diabetes mellitus (GDM) is the most common complication of pregnancy and is known to be associated with an increased risk of postpartum metabolic disease. Based on the important role that the intestinal microbiota plays in blood glucose regulation and insulin sensitivity, supplementation of probiotic and postbiotic strains could improve glucose metabolism and tolerance in GDM.
Main Methods: 56 4-week-old female C57BL/6J-mice were divided into 4 groups (n = 14 animals/group): control (CNT), high-fat/high-sucrose (HFS), pA1c® alive (pA1c®) and heat-inactivated pA1c® (pA1c®HI).
Article Synopsis
- Exercise has been identified as a factor influencing the gut microbiome, but previous findings have been inconsistent, particularly concerning specific sports.
- The study utilizes publicly available data from athlete gut microbiome research to analyze how exercise affects gut bacteria, discovering 76 species linked to exercise and identifying potential novel species through metagenomic assembly of approximately 2,000 genomes.
- The results indicate significant patterns in the microbiome associated with different sports and suggest that using metagenomics can enhance our understanding of the relationship between exercise and gut health, potentially leading to probiotic development.
strain E264 (E264) and close relatives stochastically duplicate a 208.6 kb region of chromosome I via RecA-dependent recombination between two nearly identical insertion sequence elements. Because homologous recombination occurs at a constant, low level, populations of E264 are always heterogeneous, but cells containing two or more copies of the region (Dup+) have an advantage, and hence predominate, during biofilm growth, while those with a single copy (Dup-) are favored during planktonic growth.
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- This study examines the microbial sources impacting the quality and safety of Idiazabal cheese, highlighting the diverse ecosystems present in raw milk and cheese samples.
- Major contributors to the microbiota are identified as commercial feed and teat skin, with specific bacterial genera linked to cheese quality and safety.
- The research also uncovers connections between these microbial sources and the presence of virulence and antimicrobial resistance genes, which could affect cheese production and public health.
Introduction: Effective spontaneous preterm birth (sPTB) prevention is an urgent unmet clinical need. Vaginal depletion of Lactobacillus crispatus is linked to sPTB. This trial will investigate impact of an oral Lactobacillus spp.
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