Publications by authors named "P A Baer"
Introduction: Rheumatoid arthritis (RA) guidelines recommend methotrexate (MTX)-anchored therapy with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs); however, tolerability issues often lead to non-adherence. Canadian data on MTX tapering and/or withdrawal following b/tsDMARD initiation are minimal. This chart review assessed frequency of MTX tapering or withdrawal following b/tsDMARD initiation and the impact on disease status in Canadian adults with RA.
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- The study investigates how the Influenza A virus (IAV) affects human kidney cells, specifically looking at the mechanisms behind acute kidney injury (AKI) during IAV infection.
- Researchers conducted various experiments, including infectivity assays and transcriptome/proteome analyses, revealing that IAV can replicate effectively in kidney cells.
- Findings suggest that regulated cell death plays a key role in kidney damage due to IAV, highlighting potential targets for treatment to mitigate kidney-related complications.
Solid tumors are characterized by hypoxic areas, which are prone for macrophage infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) to support tumor progression. Therefore, the crosstalk between TAMs and tumor cells is of current interest for the development of novel therapeutic strategies.
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- Marburg virus causes Marburg virus disease (MVD), a severe hemorrhagic fever with a high fatality rate, and can lead to acute kidney injury, though the exact mechanisms remain unclear.
- Studies show viral proteins in nephron cells, particularly in proximal tubular cells (PTC), indicating the virus might contribute to kidney damage in MVD.
- Research involving human PTC revealed that while the virus replicates significantly, it doesn't cause immediate cell death, instead leading to downregulation of crucial genes for kidney function and upregulation of inflammatory response genes.
The recovery of cells after tissue and organ injury is a complex process [...
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