Publications by authors named "P A Agu"
Background: There are reports of a high prevalence of maternal peripheral and placental malarial parasitaemia (MP) in southeastern Nigeria following the two-dose regimen of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment (IPT) of malaria in pregnancy.
Objective: To compare the effectiveness of monthly versus two-dose regimens of SP for IPT of malaria in pregnancy in Enugu, south-eastern Nigeria.
Methods: A randomized controlled trial involving antenatal clinic attendees at the University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria.
Malaria pervasiveness in Sub-Saharan Africa: Overcoming the scuffle.
Medicine (Baltimore)
December 2024
Malaria has posed a momentous health and economic burden to the Sub-Saharan African region. The Sub-Saharan African region accounts for more than 90% of global malaria-related mortality and morbidity. Pregnant women and children under 5 years old are the most vulnerable.
View Article and Find Full Text PDFBackground: Maternal dyslipidemia is one of the consistent metabolic changes during pregnancy. There is a controversy as to whether maternal lipid disturbances in early pregnancy are associated with adverse maternal and perinatal outcome.
Aim: To determine the effects of maternal dyslipidemia on maternal and perinatal outcomes.
Article Synopsis
- - This study explores the impact of Bisphenol A (BPA), an endocrine disruptor known to affect male fertility, on the testicular mitochondria of male albino rats and tests the protective effects of seed oil (CMSO).
- - Six groups of rats were used, with varying doses of BPA and CMSO; the study measured mitochondrial enzyme activity, membrane potential, protein levels, and body weight post-exposure.
- - Results showed that BPA reduced key mitochondrial activities and rat body weight, but coadministration of CMSO helped restore these disrupted functions, suggesting CMSO could be a potential treatment for toxins like BPA.
The modulating effects of seed oil (CPSO) on dyslipidemia and neuronal dysfunction in tramadol toxicity were studied. Fifty-six albino rats were divided into seven groups of eight rats each after a 2-week acclimatization period. All animals had unrestricted access to water and feed, and treatments were administered orally once daily for 42 days.
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