Publications by authors named "P A Aarts"
Background: Severe keloids are difficult to treat. Corticosteroid injections with needles are painful and associated with frequent recurrences. Therefore, more effective, safe and patient-friendly alternative treatments are urgently needed.
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- A 62-year-old male patient showed a unique spongy appearance of the perianal skin after undergoing surgery for hidradenitis suppurativa (HS), characterized by multiple orifices and cysts.
- Histopathological analysis revealed dilated hair follicles and keratin, suggesting that the spongy appearance was due to spontaneous shedding of cystic contents.
- The condition, termed "cystic sponge anus," may be linked to factors like HS, smoking, and male gender, requiring further research to understand its prevalence and related health issues.
Article Synopsis
- Adalimumab alone for treating hidradenitis suppurativa (HS) has a maximum effectiveness of only 60%, and its impact on draining tunnels is limited, which leads to the exploration of improving therapy with antibiotics.
- A study compared the effects of adalimumab combined with antibiotics (clindamycin and rifampicin) against adalimumab alone over 12 weeks, with results showing that the combination therapy significantly outperformed the monotherapy.
- The combination therapy resulted in greater improvements in the severity of HS, including a more significant reduction in symptoms and pain, specifically showing better outcomes in reducing draining tunnels associated with the condition.
Objectives: The treatment of recalcitrant keloids is challenging. Although intralesional bleomycin using conventional needle injectors (CNI) is effective, it has important drawbacks, such as the need for repetitive and painful injections. Therefore, we aimed to evaluate the effectiveness, tolerability and patient satisfaction of intralesional bleomycin with lidocaine administered with a needle-free electronically-controlled pneumatic jet-injector (EPI) in recalcitrant keloids.
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