Publications by authors named "Pınar Kadıoglu"
Background: Acromegaly is a disease with high morbidity and mortality rates. The role of primary care physicians is very important in the early diagnosis of acromegaly. The present study aims to determine the knowledge and attitudes of primary care physicians about acromegaly in different countries worldwide.
View Article and Find Full Text PDFThe association between change in temporal muscle mass and treatment of acromegaly.
Growth Horm IGF Res
December 2024
Purpose: We aimed to evaluate the relationship between temporal muscle thickness and GH/IGF-1 elevation and the effect of acromegaly treatment on temporal muscle thickness.
Methods: Patients with acromegaly and healthy controls were included in the study. While laboratory parameters, clinical findings and temporal muscle thickness of acromegaly patients at the time of diagnosis and one year after treatment were evaluated, laboratory parameters and temporal muscle thickness of healthy controls were evaluated only during the period when they were included in the study.
Article Synopsis
- Acromegaly, a condition caused by excessive growth hormone and IGF-1, negatively affects patients' quality of life and is conventionally treated with healthcare-administered therapies, while CAM2029 offers a self-administered option with better convenience and storage.
- A 24-week phase 3 trial involving 72 patients assessed the effectiveness of CAM2029 compared to placebo, focusing on the control of IGF-1 levels and GH.
- Results at Week 22/24 showed that CAM2029 significantly outperformed placebo in controlling IGF-1 and GH levels, leading to improved symptoms, quality of life, and patient satisfaction.
Background: Cognitive impairment is known to occur in patients with prolactinoma, but the underlying mechanism is unclear.
Objective: To evaluate cognitive function in patients with prolactinoma and to investigate the basis of possible cognitive impairment in brain white matter changes using diffusion tensor imaging (DTI).
Methods: 37 consecutive patients with prolactinoma and 37 healthy controls of similar age, sex, and education were enrolled in the study.
Objective: Primary hypophysitis might be challenging to diagnose, and there is a lack of evidence regarding optimal treatment strategies due to rarity of the disease. We aim to investigate the clinical features and compare the outcomes of different management strategies of primary hypophysitis in a large group of patients recruited on a nationwide basis.
Design: A retrospective observational study.
Purpose: The alteration of the microbiota in the mouth and gut could potentially play a role in the pathogenesis of various diseases, and conversely, these diseases may have an influence on the composition of the gut microbiota. Acromegaly disease can potentially affect physiological processes in the mouth and gut. The present study was designed to investigate the relationship between acromegaly and the oral and gut microbiota, as data on this topic are scarce.
View Article and Find Full Text PDFBackground: Current guidelines recommend dopamine agonists (DA) as the primary therapeutic approach for prolactinomas; however, emerging evidence suggests that surgical intervention can also yield favorable outcomes.
Objective: To comprehensively evaluate prolactinoma patients undergoing surgical and medical treatments at our pituitary center.
Methods: Retrospective review of mMedical records from prolactinoma patients treated between 2015 and 2022 was performedwere retrospectively reviewed.
The Association Between Oxidative Stress and Sperm Parameters in Patients with Acromegaly.
Exp Clin Endocrinol Diabetes
September 2024
Article Synopsis
- Spermatozoa are vulnerable to damage from oxidative radicals, particularly in patients with acromegaly, prompting an investigation into this relationship.
- The study assessed oxidant and antioxidant levels in the semen and serum of 22 acromegalic patients versus 14 healthy controls, revealing significantly elevated oxidant levels in the patients' semen.
- Findings indicated a negative correlation between total oxidant status and key sperm parameters, suggesting that increased oxidative stress may negatively impact semen quality in individuals with acromegaly.
Article Synopsis
- - This study aimed to identify factors affecting disease-free survival (DFS) in patients with medullary thyroid carcinoma (MTC), as previous research in this area has been limited.
- - Researchers analyzed data from 257 patients, finding that 51% had persistent/recurrent disease while 49% had no evidence of disease at follow-up, with various factors like age, metastasis, and initial response influencing DFS outcomes.
- - The key finding was that the lack of an excellent response after initial treatment is the strongest predictor of worse DFS, highlighting the need for diligent follow-up even in patients who initially respond well.
Article Synopsis
- The study focused on creating machine learning algorithms to differentiate between types of ACTH-dependent Cushing's syndrome using biochemical and radiological data.
- The research involved 106 patients and used logistic regression, achieving an average diagnostic accuracy of 86% and an AUROC value of 0.850.
- Key factors influencing the model's output included specific test results and characteristics of pituitary adenomas, and the developed algorithm is accessible to clinicians for practical use.
The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly.
Endocr Metab Immune Disord Drug Targets
February 2024
Background: The increase in portal insulin levels has been shown to upregulate growth hormone receptor expression in the liver, leading to increased insulin-like growth hormone- 1 levels. Metformin inhibits hepatic gluconeogenesis and reduces fasting insulin.
Objective: We evaluated the effect of metformin treatment in patients with acromegaly on growth hormone, insulin-like growth hormone-1, and pituitary adenoma size.
Background: Early diagnosis and effective antiretroviral therapy (ART) lead to similar life expectancy in people living with HIV (PLWH) compared to the general population. This population faces problems such as decreased bone mineral density (BMD) and increased fracture risk. The aim of this study was to determine the prevalence of osteoporosis in men aged 50 years and over who were PLWH and to determine risk factors and changes in bone metabolism with bone turnover markers.
View Article and Find Full Text PDFPurpose: To assess how living with patients with acromegaly affects people's psychology and quality of life (QoL).
Methods: Acromegaly patients and their cohabitants included in this study. Patients were administered Acromegaly Quality of Life Questionnaire (AcroQoL), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI).
Is There A Connection Between Primary Hypophysitis and Celiac Disease?
Exp Clin Endocrinol Diabetes
January 2024
Article Synopsis
- The aim of the study was to explore the connection between primary hypophysitis (PH) and celiac disease (CD) by analyzing patient records and clinical findings from 2007 to 2022.
- The study included 19 patients with lymphocytic hypophysitis, 30 celiac patients, and 30 healthy controls, finding no cases of CD in patients with PH and lower HLA-DQ2/8 detection rates in PH compared to CD.
- Results indicated significant differences in antibody levels between the groups, suggesting a potential link between autoimmune responses in PH and genetic factors associated with celiac disease.
Background: The primary treatment for patients with acromegaly has traditionally been transsphenoidal surgery, with decreasing reliance on radiotherapy (RT) due to advancements in pharmacotherapy (PT). Despite these advancements, a substantial portion of patients still face persistent acromegaly, necessitating novel treatment approaches. This study investigates the role of CyberKnife Stereotactic Hypofractionated Radiotherapy (CK-HFRT) in persistent acromegaly.
View Article and Find Full Text PDFObjective: This study evaluated short- and long-term efficacy and safety of the second-generation somatostatin receptor ligand pasireotide alone or in combination with dopamine agonist cabergoline in patients with Cushing's disease (CD).
Study Design: This is an open-label, multicenter, non-comparative, Phase II study comprising 35-week core phase and an optional extension phase. All patients started with pasireotide, and cabergoline was added if cortisol remained elevated.
Objectives: Despite the presumed overdiagnosis of papillary thyroid microcarcinoma (PTMC) which has resulted in a new trend toward less-extensive surgery and a preference for active surveillance, the impact of microscopic extrathyroidal extension (mETE) on the clinical outcomes of PTMC is still controversial. This study assessed the impact of mETE on the clinical outcomes of patients with classic subtype PTMC.
Methods: The data of consecutive patients who underwent thyroidectomy and were histopathologically diagnosed as classic subtype PTMC were analyzed.
Objective: Investigate the changes in the characteristics of presentation, in patients with acromegaly over a period of approximately half a century.
Methods: The medical records of patients diagnosed with acromegaly between 1980 and 2023 were retrospectively reviewed. The collected data were examined to assess any changes observed over the years and a comparison was made between the characteristics of patients diagnosed in the last decade and those diagnosed in previous years.
Purpose: To asses risk of new-onset impulse control disorders (ICDs) in patients with Cushing's disease (CD) who initiated cabergoline (CBG) and to determine frequency of ICDs in CBG-treated patients with CD.
Methods: This naturalistic observational study had prospective and cross-sectional arms which included patients at five referral centers based in Istanbul. Patients who were scheduled for CBG were assigned to prospective arm.
Purpose: To compare thalamic volume and cognitive functions of patients with mild autonomous cortisol secretion (MACS) with control subjects and patients with overt Cushing's syndrome (CS).
Methods: In this cross-sectional study, volumes of regions of interest were assessed using 3 T magnetic resonance imaging and a voxel-based morphometry approach in 23 patients with MACS, 21 patients with active CS, 27 patients with CS in remission, and 21 control subjects. Cognitive functions were assessed using validated questionnaires.
Objective: To investigate the initial and long-term remission rates, factors related to remission, secondary treatments, and outcomes for patients with prolactinoma who underwent endoscopic transsphenoidal surgery (ETSS).
Methods: The medical files of the 45 prolactinoma patients who underwent ETSS between 2015 and 2022 were retrospectively reviewed. Relevant demographic and clinical data were obtained.
Histologically aggressive micropapillary thyroid carcinomas (PTMC) subtypes are thought to be associated with an aggressive clinical course. However, evidence for unfavorable clinical outcomes in patients with aggressive PTMC subtypes is not clear. In this study, we intended to determine the difference in clinical outcomes between patients with aggressive and non-aggressive PTMC subtypes.
View Article and Find Full Text PDFPurpose: Various problems related to the gender-affirming therapy (GAT) can adversely affect both the physical and mental health of people diagnosed with gender dysphoria (GD). In this study, we aimed to highlight the reasons for loss to follow-up during the gender-affirming hormone therapy (GAHT), which is an important component of GAT.
Methods: People diagnosed with GD who were followed for GAHT between January 2014 and June 2019 (female-to-male: 349; male-to-female: 89) were enrolled.
Context: Dopamine agonist (DA)-induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly recognized in patients with prolactinoma.
Objective: We aimed to examine the genetic component of the underlying mechanism of DA-induced ICD.
Methods: Patients with prolactinoma receiving dopamine agonist (cabergoline) treatment were included in the study.