A computer-assisted rehabilitation program improves self-management, cognition, and quality of life in epilepsy: A randomized controlled trial.

Objective: This study aimed to evaluate the impact of a computer-assisted rehabilitation program on self-management, cognitive function, and quality of life in people with epilepsy (PwE).

Methods: A randomized controlled trial was conducted with 44 PwE (22 intervention, 22 control) at a university hospital's neurology clinic. The intervention group received 12 sessions of the RehaCom program (45 min/session, twice a week for six weeks).

Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages.

Spermatogenesis is finely regulated by histone methylation, which is crucial for regulating gene expression and chromatin remodeling. Functional studies have demonstrated that the histone lysine methyltransferases (KMTs) SETD1B, CFP1, SETDB1, G9A, and SETD2 play pivotal roles in spermatogenesis through establishing the key histone methylation marks, H3K4me3, H3K9me2, H3K9me3, and H3K36me3, respectively. This study aimed to evaluate the spatiotemporal expression of these KMTs and methylation marks as well as senescence-associated β-galactosidase (β-GAL), transcriptional activity, and apoptosis rates in mouse testes during biological aging.

Evaluation of prostheses retained zygomatic and dental implants in large defects in the maxilla due to tumors or major trauma by biomechanical 3- dimensional finite element analysis.

Background: Zygomatic implants are becoming an ideal treatment approach for implant-supported prosthesis treatment developed for the atrophic maxilla. This study aims to evaluate the amount and distribution of stress in implants and peri-implant bone using different implant-supported prosthesis configurations in Aramany Class I maxillary defects through 3-dimensional finite element analysis.

Methods: A 3-dimensional finite element model of the Aramany class I defect was created.

Synthesis and X-ray evaluation of 7 N-1S thiabendazole based 1,2,3-triazole as a dual metal sensing probe: Molecular logic gate construction, DFT analysis, real water sample analysis and catalytic activity investigation of its metal complexes.

The research aimed to develop of a thiabendazole-derived dual metal sensing probe (TBZT) for the selective detection of metal ions and to explore its metal complexes in reducing environmental pollutants like nitro-phenol and dyes. Absorption and emission based studies predicted the selectivity and sensitivity of TBZT towards Ni(II) and Co(II) ions which was further validated by HNMR, Mass, FT-IR, DFT, Docking, electrochemical, TGA studies and vibrating sample magnetometer analysis techniques. Limit of detection (LOD) values were calculated as 2 × 10 M and 4.

The clinical presentation and genetic diagnosis of Tangier disease in the pediatric age group.

Objectives: Tangier disease (TD) is a rare autosomal recessive condition characterized by high-density lipoprotein (HDL) deficiency; involving symptoms of polyneuropathy, hyperplastic orange-yellow tonsils, vision disorder, and sudden cardiac death. The major clinical symptoms of TD may not all be co-present. This study evaluates patients diagnosed with TD in childhood to improve the possibility of early diagnosis of asymptomatic cases by reporting our patients' clinical characteristics in order to minimize delayed diagnosis and emphasize the importance of TD, easily detected by HDL measurement.

Newly defined biomarker for the no reflow phenomenon in patients with non-ST elevation acute coronary syndrome; uric acid to creatinine ratio.

Background: The present study aimed to investigate whether newly defined serum uric acid (SUA) to serum creatinine ratio (SUA/SCr) predicts no-reflow phenomenon (NRP) development in patients with non-ST-elevated acute coronary syndrome (NSTE-ACS).

Methods: The study group was divided into two groups: those who developed NRP and those who did not. Complete blood counts, SUA, serum creatinine, C-reactive protein (CRP) and albumin were obtained at admission.

Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B.

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.

Modulation of FOXP3 Gene Expression in OVCAR3 Cells Following Rosmarinic Acid and Doxorubicin Exposure.

Ovarian cancer has the highest mortality rate in the world. Treatment methods are listed as surgery, chemotherapy, and radiotherapy, depending on the stage of cancer, but developing resistance to chemotherapy increases the need for alternative agents that act on the same pathways. The effects of rosmarinic acid (RA) and doxorubicin (DX) on the activation of FOXP3, an important tumor suppressor gene, in OVCAR3 cells were examined.

Molecular Markers in Embryo Non-Development: Analysis of Gene Expressions (, , ) in Spent Embryo Culture Medium.

An embryo culture medium is a specialized set of ambient conditions, technological equipment, and nutrients that embryos require to grow properly. We aimed to investigate the , , and gene expression differences between developing and non-developing embryos in spent embryo culture medium. , , and gene expressions were determined from the spent embryo culture medium containing developing and non-developing embryos of 20 normoresponder patients admitted to the Bahçeci Umut IVF Center.

A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients.

The nature of somatotroph adenomas has not been clearly revealed in studies. We consider that there are macroscopic differences in intraoperative tumor consistency in acromegaly patients. We aimed to determine whether there is a relationship between intraoperative tumor consistency and histopathological subtypes by planning a prospective study to determine whether these differences are significant.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Effectiveness of movement representation techniques in non-specific shoulder pain: a systematic review and meta-analysis.

This systematic review and meta-analysis aims to assess the effects of movement representation techniques (MRT) on pain, range of motion, functional outcomes, and pain-related fear in patients with non-specific shoulder pain (NSSP). A literature search conducted in PubMed, PEDro, EBSCO, Scopus, Cochrane Library, ScienceDirect, and gray literature on April 31, 2023. We selected seven randomized controlled trials based on the PICOS framework.

Clinicopathological features for the prediction of immunosuppressive treatment responses in sarcoidosis-related kidney involvement: a single-center retrospective study.

Background/aim: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who were treated with immunosuppressives.

Materials And Methods: Twenty-three patients with biopsy-confirmed kidney sarcoidosis were included.

The impact of tobacco consumption on household catastrophic health expenditure in Türkiye.

Background: Understanding the financial burden of smoking on households is crucial for developing effective strategies and policies to reduce smoking and mitigate its impact on household health.

Aim: To investigate the relationship between smoking and catastrophic health expenditure in Türkiye.

Methods: This cross-sectional study used microdata from household budget surveys conducted by the Turkish Statistical Institute in 2015 and 2019.

Prognostic value of circulating and tumor microenvironmental biomarkers in endometrial cancer.

Aim: Endometrial cancer (EC) is one of the three most common gynecological malignancies. Thus, it is estimated that the mortality rates due to this disease will increase. Our aim is to study the immune microenvironment in all ECs together with Hematoxylin Eosin (H&E), immunohistochemical (IHC) and Biochemical parameters (NLR) and to evaluate their contribution to prognosis by comparing them with each other.

An experimental study on the effect of non-ionizing electromagnetic fields on honey bees.

Due to the increase in data rate in mobile communication and the widespread use of mobile internet, electromagnetic communication systems are increasing daily. This situation causes increases in the use of more mobile communication devices and environmental non-ionizing Electromagnetic Field (EMF) levels. The rise of bee deaths and colony losses in beekeeping parallel to the increase of the EMF sources cause the concept of "electromagnetic pollution" to be considered among the reasons.

Differential diagnosis of submucosal gastric tumors: gastric schwannomas misdiagnosed as GISTs.

Schwannomas commonly occur in the head and neck region but are rarely seen in the gastrointestinal tract; the stomach and small intestine are the most commonly involved sites. These tumors are usually misdiagnosed as gastrointestinal stromal tumors (GISTs) before histopathological confirmation due to radiological similarity. GI schwannomas show positivity for S100 protein and vimentin but are negative for CD 117 and CD 34, which helps in differentiating the tumor from GISTs.

Corrigendum to "A rare case: Transcatheter coil embolization in a patient with cystic duct stump injury following cholecystectomy" [Radiol Case Rep J. 2025;1(20) 406-409].

[This corrects the article DOI: 10.1016/j.radcr.

Health Perceptions and Risk of Metabolic Syndrome and Diabetes in Psychiatric Patients.

Introduction: People with serious psychiatric disorders requiring long-term care and treatment are known to have higher rates of various physical diseases and early mortality.

Aim: This study aimed to evaluate health perceptions and risk of metabolic syndrome and diabetes in patients with psychiatric disorders.

Method: Data were collected from a group of 228 patients using the Health Perception Scale, the Metabolic Syndrome Assessment Form and the American Diabetes Association Diabetes Risk Test.

Prevalence of Arrhythmias in Patients With Coronary Microvascular Dysfunction.

Background: Coronary microvascular dysfunction (CMD) is an important cause of angina with nonobstructive coronary arteries (ANOCA). It is unclear whether CMD is associated with arrhythmia.

Aims: This study aimed to evaluate the prevalence of arrhythmias in patients with ANOCA and CMD compared to those in patients with ANOCA without CMD.

Gallic Acid Induces HeLa Cell Lines Apoptosis via the P53/Bax Signaling Pathway.

Background: Cervical cancer is a type of cancer that originates from the endometrium and is more common in developed countries and its incidence is increasing day by day in developing countries. The most commonly prescribed chemotherapeutic drugs limit their use due to serious side effects and the development of drug resistance. For this reason, interest in new active ingredients obtained from natural products is increasing.

Endoscopic Endonasal Approach for Calcified Sellar/Parasellar Region Pathologies: Report of 11 Pituitary Adenoma Cases.

Objective: Calcification in pituitary adenomas is a rare occurrence and its differential diagnosis typically includes other sellar masses. Common calcifications in pituitary adenomas are classified into 2 morphological forms: capsular (eggshell-like) and multiple small nodular calcifications located within the adenoma. Also, there is a pituitary stone term.

Effect of CAD-CAM block thickness and translucency on the polymerization of luting materials.

Aim: This in-vitro study aimed to evaluate the degree of conversion (DC) of dual-cured luting cement (Bifix QM, VOCO) and flowable composite (Grandio Flow, VOCO) under lithium disilicate glass-ceramic (IPS e.max CAD, Ivoclar Vivadent) and hybrid ceramic (Grandio Blocs, VOCO; Cerasmart, GC) CAD-CAM blocks with different thicknesses.

Materials And Methods: Contrast ratio (CR), translucency (TP, TP), and opalescence (OP) parameters of 30 disc-shaped CAD-CAM blocks (n = 5) prepared with two different thicknesses (1.

The Relationship between the Improvement Level in Blood Gas Parameters in Time and Brain MRI Findings in Newborns with the Diagnosis of Hypoxic Ischemic Encephalopathy.

Objective: In this study, we aimed to evaluate the relationship between the level of improvement in blood gas parameters in the first hours of age and normal and diffusion-restriction brain magnetic resonance imaging (MRI).

Materials And Methods: The study is a retrospective cohort study. Cases of the diagnosis of hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia in our unit between January 2022 and January 2024 were included in the study.