Exploring key features of selectivity in somatostatin receptors through molecular dynamics simulations.

Somatostatin receptors (SSTRs) are widely distributed throughout the human body and play crucial roles in various physiological processes. They are recognized as key targets for both radiotherapy and radiodiagnosis due to their overexpression in several cancer types. However, the discovery and design of selective drugs for each of the five isoforms have been significantly hindered by the lack of complete structural information.

Changes in immature granulocyte levels and their association with disease activation following biologic therapy in patients with ankylosing spondylitis.

Introduction: AS is a chronic disease with an inflammatory serum microenvironment characterized by increased oxidative stress (OS). Along with OS, reactive oxygen species (ROS) are elevated in patients with AS. Overexpression of ROS causes active inflammatory processes leading to the secretion of pro-inflammatory factors, including tumor necrosis factor-alpha (TNF-α).

Comparison of supination/flexion maneuver to hyperpronation maneuver in the reduction of radial head subluxations: A randomized clinical trial.

Objective: This randomized controlled trial aimed to compare the effectiveness of supination/flexion (SF) and hyperpronation (HP) maneuvers in the management of radial head subluxation (RHS) in children ≤6 years old presenting to the emergency department.

Methods: Patients were randomly allocated to one of two treatment arms. Following the application of the respective reduction maneuver, maneuver success was assessed after 10 min.

Mesophilic versus thermophilic digestion of sludge in anaerobic membrane bioreactors.

Energy-efficient wastewater treatment plants (WWTPs) utilize systems like high-rate activated sludge (A-stage) system to redirect organics from wastewater are redirected into energy-rich sludge (A-sludge). Anaerobic membrane bioreactors (AnMBRs) offer lower footprint and higher effluent quality compared to conventional digesters. In this study, the biological treatment and the filtration performances of AnMBRs for A-sludge digestion under mesophilic and thermophilic conditions were comparatively evaluated through lab-scale experiments, mass balancing and dynamic modeling.

Radiomics-Based Diagnosis in Dentomaxillofacial Radiology: A Systematic Review.

Radiomics is a quantitative tool for digital image analysis. This systematic review aims to investigate the scientific articles to evaluate the potential implications of Radiomics analysis in Dentomaxillofacial Radiology (DMFR). Studies regarding Radiomics applications in DMFR and human samples, in vivo study, a case reports/series if ≧5 samples were included, while case reports/series if < 5 samples, articles other than in English, abstracts without full text, and studies published before 2015 were excluded.

Adjuvant Chemotherapy Duration and Disease-Free Survival in Low-Risk Stage III Colon Cancer with N1a-b and N1c Disease: Insights from a Single-Center Retrospective Analysis.

Background: Tumor deposits (TDs) are known to have a poor prognosis independent of lymph node (LN) involvement and are considered equivalent to LN metastases in the latest staging system. In stage III colon cancer (CC), high-risk patients (pT4 or pN2) receive 6 months of adjuvant chemotherapy, while low-risk patients (pT1-3 and N1) are recommended either 3 or 6 months of CAPOX or 6 months of FOLFOX therapy. However, the optimal chemotherapy duration for low-risk patients classified as pN1c remains unknown.

Establishing Composition of Solid Solution Based on Single Crystal and Powder X-ray Measurement: The Case of Halogenated Bismuth(III) Complexes with Acetophenone-4-methyl-3-thiosemicarbazone.

New bismuth (III) complexes with acetophenone-4-methyl-3-thiosemicarbazone (L) and halogens (Cl and Br) in both bridging and terminal positions have been synthesized and structurally characterized using single-crystal X-ray diffraction. The pure complexes (Cl or Br) were found to be highly isostructural, which motivated our attempts to create solid solutions of these complexes. A series of such compounds was prepared using various procedures and stoichiometries.

Group VA Aromatic Thiosemicarbazone Complexes: Synthesis, Characterization, Biological Activity, and Topological Studies.

The antiproliferative and antibacterial activities of thiosemicarbazones increase markedly with the presence of metal ions. One of the factors determining the activity of metal thiosemicarbazone complexes is the coordination structure. In this study, the biological effects of new antimony (III) and bismuth (III) thiosemicarbazone complexes with different binding modes and geometrical structures were demonstrated.

Force Fields, Quantum-Mechanical- and Molecular-Dynamics-Based Descriptors of Radiometal-Chelator Complexes.

Radiopharmaceuticals are currently a key tool in cancer diagnosis and therapy. Metal-based radiopharmaceuticals are characterized by a radiometal-chelator moiety linked to a bio-vector that binds the biological target (e.g.

Surgical outcomes of cable plate fixation in treatment of Vancouver type B1 and type C periprosthetic femoral fractures: a retrospective case series.

This study aimed to investigate the mid-to-long-term surgical outcomes of open reduction and internal fixation (ORIF) using a hybrid locking plate/cable technique for the treatment of Vancouver type B1 and type C periprosthetic femoral fractures (PPFs) in a consecutive group of patients from a single tertiary referral center. Twenty-five patients (25 PPFs; 17 female, 8 male) in whom a Vancouver type B1 or type C PPF was diagnosed and treated by a hybrid locking plate/cable technique from 2005 to 2016 were included in the study. Patients' functional status was categorized into 4 groups based on the Harris Hip Score (HHS) at the final follow-up: 70=poor result; 70-80=fair; 80-90=good, and 90-100=excellent.

Navigating the impact of remittances on environmental quality in Africa: The crucial role of institutional quality.

The Sub-Saharan African (SSA) region remains the world's largest recipient of remittances. Due to growing concerns over climate change issues, recent studies have examined how these financial flows have affected environmental quality. Sundry variables were controlled in such studies concerning the remittances-environment nexus, including institutional quality.

Comparison of optical coherence tomography angiography results in patients with internal carotid artery stenosis who underwent carotid artery stenting and carotid endarterectomy.

It is important to examine the ocular hemodynamic changes after carotid artery stenting (CAS) and carotid endarterectomy (CEA) in patients with internal carotid artery stenosis (ICAS). We aimed to compare the differences in retinal and optic nerve head blood flow after 2 surgical methods. The ipsilateral eyes of 34 patients who had over 50% ICAS with no ocular findings and 30 healthy controls were included in the study.

The diagnostic accuracy of cone beam computed tomography in detecting temporomandibular joint bony disorders: a systematic review.

Computed tomography (CT) has been recognized as a robust and dependable technique for delineating osseous alterations and anomalies within hard tissues. The necessity for accurate diagnosis and management of patients with temporomandibular disorders in dental practices has increasingly come to the forefront. There is ongoing scholarly debate regarding the equivalence of diagnostic outcomes yielded by cone beam computed tomography (CBCT), which offers greater accessibility in dental settings than traditional CT, in identifying bony changes within the temporomandibular joint (TMJ).

Pathway to environmental sustainability: Assessing the role of productive capacity, remittances, and uncertainty in sub-Saharan Africa.

Unlike previous studies that have examined the association between different economic development parameters and environmental sustainability, the present study utilised an index of productive capacity to offer an in-depth understanding of the ecological impact of improving a nation's productive resources. It also emphasised the importance of remittances in reducing environmental degradation in uncertain economic and political environments. This study applied the system GMM technique and an advanced panel quantile regression technique to 36 Sub-Saharan Africa (SSA) region countries from 2000 to 2022.

Therapeutic Effect of Melatonin on CCl-Induced Fibrotic Liver Model by Modulating Oxidative Stress, Inflammation, and TGF-β1 Signaling Pathway in Pinealectomized Rats.

The study aimed to determine the CCl-induced liver fibrosis model in pinealectomized rats and biochemically, immunohistochemically, and histopathologically investigate the therapeutic effect of melatonin on liver fibrosis. The surgical procedure for pinealectomy was performed at the beginning of the study, and the sham and pinealectomized rats were administered CCl dissolved in corn oil (1:1) alone every other day to induce liver fibrosis or together with melatonin (10 mg/kg) therapy for 15 days. Melatonin is an essential therapeutic agent and offers an alternative therapeutic strategy in CCl-induced liver fibrosis by suppressing inflammation, oxidative stress, and the TGF-β1 signaling pathway.

Unleashing sustainability in uncertain times: Can we leverage economic complexity, uncertainty, and remittances to combat environmental degradation?

Rapid economic growth and human activities have seriously damaged the environment and hindered the achievement of Sustainable Development Goals (SDGs). Hence, this study aims to explore the impact of economic complexity, uncertainty, and remittance on environmental degradation in 134 countries from 2000 to 2022. In addition, it examines whether uncertainty moderates the relationship between remittance and environmental degradation.

Eco-consciousness to eco-consumption: unraveling the drivers of sustainable consumption behavior under the mediated-moderated Model.

The impact of climate change has malformed the world's ecosystem, thus making humans call for environmental protection. Climate change, the biggest trauma of the twenty-first century, has made humans switch towards natural consumption. In this regard, the growing phenomenon of industrialization has spurred consumers to invest more in ecological products.

Resilience and challenges of peritoneal dialysis survivors in the aftermath of the 2023 Kahramanmaraş earthquake.

Introduction: Peritoneal dialysis (PD) remains understudied in disaster nephrology. This retrospective multicenter study explores the experiences of PD survivors following the February 6, 2023, Kahramanmaraş Earthquake.

Methods: Adult PD patients from 11 affected cities were analyzed to assess challenges faced during and postearthquake, alongside clinical outcomes.

Corrigendum: Health in Germany: Establishment of a population-based health panel.

[This corrects the article DOI: 10.25646/11992.2.

Erratum: Health in Germany: Establishment of a population-based health panel.

[This corrects the article on p. 2,21 in vol. 9, PMID: 38282983.