Three-year clinical performance of direct restorations using low-shrinkage Giomer vs. nano-hybrid resin composite.

Objectives: The objective of this investigation was to compare the clinical performance of a nano-hybrid resin composite and a low-shrinkage Giomer resin composite.

Material And Methods: In total, 35 pairs of restorations were performed using either low-shrinkage Giomer (Beautifil II LS, Shofu Inc.) or nano-hybrid (Clearfil Majesty Posterior) resin composite in 35 patients by two operators using the relevant adhesives, i.

A systematic review of the blockchain application in healthcare research domain: toward a unified conceptual model.

Recently, research on blockchain applications in the healthcare research domain has attracted increasing attention due to its strong potential. However, the existing literature reveals limited studies on defining use cases of blockchain in clinical research, categorizing and comparing available studies. Therefore, this study aims to explore the significant potential and use cases of blockchain in clinical research through a comprehensive systematic literature review (SLR).

Association Between Dipeptidyl Peptidase-4 Inhibitor Use and Cognitive Functions, Brain-Derived Neurotrophic Factor, and Pentraxin-3 Levels in Patients With Type 2 Diabetes.

Background Diabetes mellitus is an important risk factor for dementia, Alzheimer's disease, and other neurodegenerative diseases. Recent findings have made the relationship between the inhibition of the dipeptidyl peptidase-4 (DPP-4) enzyme and cognitive functions an important research topic. Objective This study aimed to evaluate the association between DPP-4 inhibitor use and cognitive functions, serum brain-derived neurotrophic factor (BDNF), and pentraxin-3 (PTX-3) levels in patients with type 2 diabetes, compared with the patients who only use metformin treatment.

MEFV gene pathogenic variants: a risk factor for dysmenorrhea in the Turkish population.

Background/aim: The Mediterranean fever (MEFV) gene codes for protein pyrin, which is among the modulators of inflammasome activity in innate immune cells. It was suggested that there is a relation between MEFV variations and inflammatory diseases. The aim of this study was to investigate MEFV gene variations in the patients with primary dysmenorrhea.

Relationship of The Characteristic Imaging Findings of Breast Cancer with Molecular Subtypes in Young Women.

Background: The characteristic imaging findings of breast cancer in young women are not yet fully understood. It causes a delay in diagnosis by mixing with benign findings.

Objective: To evaluate the relationship between the imaging and histopathological features of breast cancer in women aged under 40 years.

The relationship between kinesiophobia and physical activity levels, gestational weight gain, and musculoskeletal pain in pregnant women.

The aim of this cross-sectional study was to investigate the effect of kinesiophobia on musculoskeletal pain, physical activity levels, and gestational weight gain in pregnant women. One hundred and sixty-three pregnant women participated in the study by completing a personal characteristics information form along with the Tampa Scale of Kinesiophobia, the Pregnancy Physical Activity Questionnaire, and the Cornell Musculoskeletal Discomfort Questionnaire. The results showed a weak negative correlation between total physical activity scores and Tampa Scale of Kinesiophobia scores ( = .

Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study.

Purpose: The clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions.

Methods: This retrospective multicenter analysis included 1.

Clinical Evaluation of Low-shrinkage Bioactive Material Giomer Versus Nanohybrid Resin Composite Restorations: A Two-year Prospective Controlled Clinical Trial.

This study evaluated the clinical performance of low-shrinkage bioactive resin composite compared with a conventional nanohybrid resin composite. A total of 35 patients (18 males, 17 females; mean age: 29±9 years old) received, randomly, 35 pairs of fillings restored with either low-shrinkage bioactive material employing Giomer filler technology (Beautifil II LS, Shofu Inc, Kyoto, Japan) or conventional nanohybrid resin composite (Clearfil Majesty Posterior, Kuraray, Japan) in Class I and Class II cavities. Two operators made all the restorations using the corresponding adhesive resins: FL-Bond II (Shofu Inc) and Clearfil SE Bond (Kuraray), according to each manufacturer's instructions.

Unilateral Axillary Lymphadenopathy after the Inactivated SARS-COV-2 (CoronaVac) Vaccine: Ultrasonographic Imaging.

Background: Currently, unilateral clinical and subclinical axillary adenopathy cases associated with the Pfizer-BioNTech and Moderna vaccines are increasingly reported. However, only one study on axillary adenopathy due to the CoronaVac vaccine is published.

Aims: To present the incidence, severity, and ultrasonographic findings of axillary adenopathy that developed in healthcare professionals in Turkey after they were vaccinated with CoronaVac against coronavirus disease-19.

Multimodal surveillance of SARS-CoV-2 at a university enables development of a robust outbreak response framework.

Background: Universities are vulnerable to infectious disease outbreaks, making them ideal environments to study transmission dynamics and evaluate mitigation and surveillance measures. Here, we analyze multimodal COVID-19-associated data collected during the 2020-2021 academic year at Colorado Mesa University and introduce a SARS-CoV-2 surveillance and response framework.

Methods: We analyzed epidemiological and sociobehavioral data (demographics, contact tracing, and WiFi-based co-location data) alongside pathogen surveillance data (wastewater and diagnostic testing, and viral genomic sequencing of wastewater and clinical specimens) to characterize outbreak dynamics and inform policy.

Identification of fungi found on desiccated human remains in an arid outdoor environment.

Three fungi not previously reported on desiccated human remains were identified on cadavers at the Forensic Investigation Research Station (FIRS) in Whitewater, Colorado. The location of the FIRS provides the unique opportunity to observe the stages of decomposition in a high desert environment. The two cadavers used in the study were in the late stages of decomposition (PMI of approximately 1520 and 1820 days) to the point of desiccation and had developed an extensive black crust on the skin that remained.

Retrospective evaluation of peripartum hysterectomy patients: 8 years' experience of tertiary health care.

Background: Peripartum hysterectomy (PPH), which means surgical removal of the uterus during pregnancy or postpartum period, is a life-saving procedure performed as a last resort to stop obstetric serious bleeding.

Aim: Evaluation of the prevalence, risk factors, indications, associated complications, and neonatal outcomes of PPH performed in our clinic.

Patients And Methods: A total of 35 patients who underwent PPH in our clinic between 2013 and 2020 were analyzed retrospectively.

Does fetuin-A mediate the association between pro-inflammatory diet and type-2 diabetes mellitus risk?

Introduction: recent studies indicate that diet increases T2DM risk via inflammation. Fetuin-A, identified as an acute-phase protein, plays a role in insulin resistance and is an independent predictor of type-2 diabetes. Objectives: the present study aimed to examine the association between diet and T2DM risk, and whether said association is mediated by fetuin-A, and to determine the effect of fetuin-A on T2DM risk.

Effect of alpha-tocopherol and dose sensitivity on pancreatitis formation in rats with experimental pancreatitis.

Background: Acute pancreatitis is an inflammatory disease accompanied by pancreatic inflammation characterized by acinar cell damage and leukocyte infiltration in the tissue. At present, mortality and morbidity rates are high despite the current treatment of pancreatitis; therefore, new studies and treatment studies are needed. In this study, the effects of alpha-tocopherol on different doses of L-arginine-induced experimental acute pancreatitis model were investigated.

Biology of an Adventive Population of the Armored Scale a Biological Control Agent of in California.

(giant reed) is invasive in Mediterranean, sub-, and tropical riparian systems worldwide. The armored scale is approved for biocontrol in North America, but an adventive population was recently discovered in southern California. We documented this population's distribution, phylogeny, phenology, potential host spillover to .

Effect of transcutaneous electrical nerve stimulation on quality of recovery and pain after abdominal hysterectomy.

Background And Aims: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive complementary therapy for postoperative pain management. The effect of TENS on quality of recovery (QoR) and pain treatment in the early postoperative period is not well documented. The aim of this study was to evaluate the effect of TENS on postoperative QoR and pain in patients who had undergone a total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO).

The impact of dysmenorrhea on pulmonary functions.

Background: Primary dysmenorrhea (PD) is characterized by symptoms including sweating, headache, nausea, vomiting, diarrhea, tremulousness, usually begins adolescence, those can be associated with autonomic dysfunction affecting pulmonary functions.

Aim: The aim of the present study is to investigate the impacts of PD on pulmonary function tests.

Subjects And Methods: A prospective cross-sectional design was selected.

VNTR Variant of the eNOS Gene and its Relationship with Osteoporosis in Postmenopausal Turkish Women.

Background: Osteoporosis (OP) is the most common type of systemic bone disease characterized by low bone mass and micro-structure deterioration of bone tissue, with a consequent increase in bone fragility and fracture risk. Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS) in endothelial cells, has considerable effects on bone cell function. The objective of this case-control study was to investigate the potential association between the eNOS gene Variable Number Tandem Repeat (VNTR) variant and susceptibility of OP, in Turkish postmenopausal female patients.

Effect of surface sealant on the surface roughness of different composites and evaluation of their microhardness.

Purpose: The aim of this study was to evaluate the effect of a surface sealant on the surface roughness of different composites and compare their microhardness values.

Materials And Methods: Sixty disc-shaped specimens were prepared and assigned to 6 groups (n =10). Groups were prepared as follows; Group 1 (Herculite XRV Ultra), Group 2 (Beautifil Bulk Restorative) and Group 3 (Filtek Bulk Fill Posterior Restorative).

To Evaluate Choroidal and Retinal Thicknesses in Singleton versus Twin Pregnancies using Optical Coherence Tomography.

Purpose: The purpose of the study was to evaluate the choroidal and retinal thicknesses in singleton versus twin pregnancies.

Materials And Methods: This study included 20 single and 20 twin pregnant women in their 3 trimester with 20 age-matched healthy nonpregnant women as a control group. All participants underwent a detailed ocular examination.

Mitochondrial Genome Sequences of and , Two Beetle Species Introduced to North America for Biological Control.

We announce the complete circularized mitochondrial genome assemblies of and , beetle species introduced to North America for the biological control of invasive shrubs of the genus L. (Tamaricaceae). The assemblies (16,232 and 16,298 bp, respectively) each comprise 13 protein-coding genes, 22 tRNAs, two rRNAs, and a noncoding region.

Genome-wide identification of CAMTA gene family members in Phaseolus vulgaris L. and their expression profiling during salt stress.

The calmodulin-binding transcriptional activator (CAMTA) family was first observed in tobacco (NtER1) during a screening for the CaM-binding proteins, which are known to be one of the fast response stress proteins. Due to the increased importance of plant transcription factors in recent years; genome-wide identification of CAMTA genes has been performed in several plant species, except for Phaseolus vulgaris. Therefore, our aim was to identify and characterize CAMTA genes in P.

Is it beneficial to use clinical scoring systems for acute appendicitis in adults?

Background: Clinical scoring systems have been used to reduce negative appendectomy rate for several decades. However, the use of these systems has been questioned due to differences in their diagnostic accuracies. The aim of this prospective study was to develop a new clinical scoring system using a combination of all previously described variables for the diagnosis of acute appendicitis (AA).

Analysis of estrogen and progesterone receptor gene polymorphisms in leiomyoma.

Background: Leiomyoma, one of the most common benign tumors, causes morbidity during the reproductive years in women. The molecular pathogenesis of the disease is not clear. Leiomyomas are hormone-sensitive tumors affecting around 20%-25% of women.