Antiprotozoal activity of natural products from Nigerien plants used in folk medicine.

In the course of the screening of plants from Niger for antiprotozoal activity, the methanol extract of , and the dichloromethane extracts of and were found to be active against protozoan parasites, namely , , and/or . Myricitrin (), quercitrin () and 1-palmitoyl-lysolecithin () were isolated from . From , the three triterpene derivatives , , and are described here for the first time.

Isolation and Structure Elucidation of Compounds from and Their Antiproliferative Activity against Multiple Myeloma Cells.

The phytochemical investigation of the dichloromethane root extract of led to the isolation of 18 compounds. Among these, compounds -, defined as 9-hydroxy-2,2-dimethyl-2-benzo[]chromene-5,10-dione 6--β-d-glucopyranoside (), (2,3)-3,4,7-trihydroxy-2-(3'-methylbut-2'-en-1'-yl)-2,3-dihydro-1-inden-1-one (), ()-2-(1',4'-dihydroxy-4'-methylpent-2'-en-1'-ylidene)-4,7-dihydroxy-1-indene-1,3(2)-dione (), ()-2,5,8-trihydroxy-3-(2'-hydroxy-3'-methylbut-3'-en-1'-yl)naphthalene-1,4-dione (), 6-hydroxy-3-(3'-methylbut-2'-en-1'-yl)-4-oxo-4-chromene-5-carboxylic acid (), and ()-2-(1'-hydroxy-4'-methylpent-3'-en-1'-yl)anthracene-9,10-dione (), respectively, have not yet been described. Their structures were elucidated based on spectroscopic data analysis, including IR, NMR, HRESIMS and ECD measurements.

Isolation and Structural Elucidation of Compounds from and Their In Vitro Antiprotozoal Activity.

Species of the genus are used in traditional medicine against fever and malaria. The present study focuses on the isolation and identification of bioactive compounds from extracts, and the evaluation of their antiprotozoal activity. Fractionation and isolation combined to LC-HRMS/MS-based dereplication provided 16 compounds: seven indole alkaloids, four indoline alkaloids, two secoiridoid glycosides, two iridoid glycosides, and one phenolic glucoside.