Botulinum toxin modulates the blink reflex via the trigeminal afferent system in hemifacial spasm: an early and late-term effect.

Background: There is growing evidence that botulinum neurotoxin (BoNT) can mediate changes at the central level through peripheral mechanisms, leading to alterations in central sensorimotor integration. However, the effect of BoNT on brainstem excitability in patients with hemifacial spasm(HFS) is not yet fully understood, and its long-term effects remain unknown.

Objective: This study aims to investigate the impact of BoNT on the excitability of the facial nucleus in patients with idiopathic HFS.

Imagining Speeds up the Effect of Motor Imagery on Central Motor Conduction Time.

Introduction: Although motor imagery (MI) has been reported to increase motor cortical excitability, its effect on central motor conduction time (CMCT), a widely used neurophysiological diagnostic method, has not been investigated. In this study, we sought to determine the effect of MI on CMCT.

Methods: In this cross-sectional study, 21 healthy volunteers (11 females, 10 males) aged 24 to 67 years (mean age: 38.

Somatosensory temporal discrimination analysis reveals impaired processing in amyotrophic lateral sclerosis.

Introduction/aims: While amyotrophic lateral sclerosis (ALS) is primarily characterized as a motor system disorder, there is a growing body of evidence indicating sensory involvement. This study aimed to examine the hypothesis that somatosensory processing is impaired in ALS.

Methods: Study participants were ALS patients followed at the Neuromuscular Outpatient Unit, as well as healthy volunteers, from March 2021 to July 2023.

Exploring the effect of the nerve conduction distance on the MScanFit method ofmotor unit number estimation (MUNE).

Objective: MScanFit motor unit number estimation (MUNE) is a sensitive method for detecting motor unit loss and has demonstrated high reproducibility in various settings. In this study, our aim was to assess the outputs of this method when the nerve conduction distance is increased.

Methods: MScanFit recordings were obtained from the abductor digiti minimi muscle of 20 healthy volunteers.

Impact of Acute High-intensity Interval Training on Cortical Excitability, M1-related Cognitive Functions, and Myokines: A Randomized Crossover Study.

High-intensity interval training (HIIT) is a time-efficient, safe, and feasible exercise type that can be utilized across different ages and health status. This randomized cross-over study aimed to investigate the effect of acute HIIT on cortical excitability, M1-related cognitive functions, cognition-related myokines, brain-derived neurotrophic factor (BDNF), and Cathepsin B (CTSB). Twenty-three sedentary young adults (mean age: 22.

Excitability of somatosensory cortex is increased in ALS: A SEP recovery function study.

Objective: Neuronal loss in the somatosensory, as well as the motor cortex in amyotrophic lateral sclerosis (ALS), indicative of a structural abnormality has been reported. Previously we have shown that afferent inhibition was impaired in ALS, suggestive of sensory involvement. In this study, we aimed to evaluate excitability changes in the somatosensory cortex of ALS patients.