Prediabetes and mild hepatosteatosis are associated with blunted cortisol response to glucagon but not to growth hormone.

Background: Although there is a close relationship between cortisol and growth hormone (GH) levels, glucose intolerance and hepatosteatosis, changes in GH and the hypothalamo-pituitary-adrenal (HPA) axis were not previously studied in prediabetes. The main purpose of the present study was to assess changes in GH and HPA axis and their relationship with hepatosteatosis in prediabetic patients.

Methods: Forty prediabetic patients, with body-mass index (BMI) 25-35kg/m, and 23 healthy individuals, with normal glucose tolerance and similar age and BMI, were included.

(E)-2-[(2-Chloro-phen-yl)imino-meth-yl]-4-methyl-phenol.

The mol-ecule of the title compound, C(14)H(12)ClNO, adopts the enol-imine tautomeric form, with an intra-molecular O-H⋯N hydrogen bond. In the mol-ecule, the two benzene rings are twisted with respect to each other by 30.6 (2)°.