Publications by authors named "Ozlem Altundag-Erdogan"
Article Synopsis
- Cancer stem cells (CSCs) are crucial in tumor development and resistance to treatments, and oleuropein, a compound from olive leaves, has promising anti-cancer properties by killing CSCs and enhancing chemotherapy effectiveness.
- The study focuses on targeting resistant CSCs using oleuropein encapsulated in methacrylated alginate (OLE-mALG) within a realistic tumor environment to improve treatment outcomes.
- Methods included creating a 3D breast cancer model and testing this OLE-mALG for its ability to reduce CSC viability and induce apoptosis, ensuring effective delivery and performance of the compound.
Telocytes have some cytoplasmic extensions called telopodes, which are thought to play a role in mitochondrial transfer in intercellular communication. Besides, it is hypothesized that telocytes establish cell membrane-mediated connections with breast cancer cells in coculture and may contribute to the survival of neoplastic cell clusters together with other stromal cells. The aim of this study is to investigate the contribution of telocytes and telocyte-derived mitochondria, which have also been identified in breast tumors, to the tumor development of breast cancer stem cells (CSCs) via miR-146a-5p.
View Article and Find Full Text PDFBackground: This study aims to investigate the roles of telocytes on the metastatic properties of breast cancer stem cells (CSCs), and to re-evaluate the effect of miR-21-5p expression on CSCs following the addition of telocytes.
Methods And Results: Telocytes from human bone marrow mononuclear cells were isolated/characterised. This was followed by the isolation/characterisation of CSCs from the MDA-MB-231.