A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.

Study Question: Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility?

Summary Answer: Our findings revealed a significant association between SPGF and the gene and identified three novel genes (, , and ) along with 32 potentially pathogenic rare variants in 30 genes that contribute to this condition.

What Is Known Already: SPGF is a major cause of male infertility, often with an unknown aetiology. SPGF can be due to either multifactorial causes, including both common genetic variants in multiple genes and environmental factors, or highly damaging rare variants.

Rate of testicular histology failure in predicting successful testicular sperm extraction.

Background: The management of Non-Obstructive (NOA) Azoospermia or Obstructive Azoospermia (OA) patients relies on testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI). In NOA patients the sperm recovery is successful in only 50% of cases and therefore the ability to predict those patients with a high probability of achieving a successful sperm retrieval would be a great value in counselling the patient and his partner. Several studies tried to suggest predictors of a positive TESE (e.

Reproductive and obstetric outcomes in TESE-ICSI cycles: A comparison between obstructive and non-obstructive azoospermia.

Purpose: Comparison of intracytoplasmic sperm injection cycles with testicular sperm extraction in obstructive azoospermia and non-obstructive azoospermia are limited, and few studies have addressed obstetric and neonatal outcomes.

Design: This study analyzed couples who underwent testicular sperm extraction-intracytoplasmic sperm injection cycles for obstructive azoospermia and non-obstructive azoospermia to determine whether impaired spermatogenesis in non-obstructive azoospermia patients would lead to worse reproductive outcomes and higher rates of pregnancy complications and fetal anomalies. This study is a retrospective, single-center analysis of all testicular sperm cycles performed between January 1, 2001 and December 31, 2020.

Client-centered lifestyle intervention for men with fibromyalgia syndrome: Is efficacy independent of gender?

Aim: Fibromyalgia syndrome (FMS) has a significant impact on daily life, but the fact that most diagnosed individuals are women makes it difficult to understand the occupational needs and lifestyle choices of male patients. The purpose of this study was to examine the effectiveness of a client-centered lifestyle intervention program in men with fibromyalgia and compare it with women.

Methods: The client-centered lifestyle intervention program was applied to 15 men with fibromyalgia in two sessions per week for 4 weeks in individual sessions and compared with data from 15 women who had previously participated in the same program.

The effectiveness of a client-centered lifestyle intervention in women with fibromyalgia syndrome: A quasi-experimental controlled study.

In this study, the authors aimed to investigate the effects of a client-centered lifestyle intervention for women with fibromyalgia syndrome on the levels of disease severity, occupational participation, anxiety, depression, and life satisfaction. The quasi-experimental controlled study was conducted at Occupational Therapy Department of Hacettepe University in Turkey between January 2018 and May 2018. Based on the literature review and basic assessments, a lifestyle intervention program was designed focusing both on the participants' occupational goals and the effects of fibromyalgia symptoms.

Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction.

Background: Matrix metalloproteinases (MMPs) are thought to promote progression of atherosclerosis and cardiovascular complications such as plaque rupture. It has been suggested that, on tumor cells, the extracellular MMP inducer (EMMPRIN) is involved in MMP synthesis by as yet unknown mechanisms. On cardiovascular cells, regulation of EMMPRIN in vivo or any functional relevance for MMP induction in vitro has not yet been studied.

Plasminogen and matrix metalloproteinase activation by enzymatically modified low density lipoproteins in monocytes and smooth muscle cells.

Protease activity promotes the progression and rupture of atherosclerotic plaques. LDL has been described to become enzymatically modified within the vessel wall yielding an atherogenic moiety (E-LDL). We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases (MMPs) in monocytes and vascular smooth muscle cells (VSMCs) as well as on MMP activation during cellular interactions.