The effectiveness and safety of botulinum toxin treatment for sialorrhea due to severe brain injury.

Introduction: Sialorrhea may be a consequence of severe acquired brain injury (ABI). Salivary gland botulinum neurotoxin (SG-BoNT) injections can reduce saliva production, but there is limited evidence for their use in ABI.We reviewed the effectiveness, impact on chest infection frequency, and safety of SG-BoNT for sialorrhea in a cohort of patients with severe ABI.

Outcome of Soft Tissue Popliteal Sarcomas: 15 Years of Experience.

Background: Soft-tissue sarcoma involving the popliteal fossa remains challenging because it is difficult to achieve wide margins with limb salvage in this location. Adjuvant therapy is frequently necessary, and limb function can be adversely affected. We reviewed our experience with these tumors.

Evaluating the performance of the MSKCC gastric cancer survival calculator in the Turkish population.

Background/aim: The Memorial Sloan Kettering Cancer Center (MSKCC) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population.

Materials And Methods: Gastric cancer patients over 18 years of age who were admitted to our clinic between 2000 and 2019 and underwent primary curative surgery and R0 resection were included in the study.

Headache Disability Questionnaire: cross-cultural adaptation and validation of the Turkish version.

Background: The Headache Disability Questionnaire (HDQ) evaluates pain intensity, daily activities, work/school disruptions, and the impact on recreational activities. It was aimed to translate the HDQ into Turkish and evaluate its reliability and validity.

Methods: This study included 130 participants, consisting of 105 females and 25 males.

Benefits of transitioning from transperitoneal laparoscopic to retroperitoneoscopic adrenalectomy-a single center experience.

Background: Since 2017, switching from laparoscopic transabdominal adrenalectomy (LTA), posterior retroperitoneoscopic adrenalectomy (RPA) is used as standard procedure in this institution. Aim of this retrospective study was to compare both techniques regarding operative time, length of stay and safety of the procedures.

Methods: All patients operated in our institution for adrenal tumors were prospectively documented in the EUROCRINE-database and retrospectively analyzed.

Investigating the geography of thought across 11 countries: Cross-cultural differences in analytic and holistic cognitive styles using simple perceptual tasks and reaction time modeling.

This article investigates cross-cultural differences in analytic/holistic cognitive styles among participants from 11 countries: Armenia, Australia, Brazil, Bulgaria, Czechia, Germany, Ghana, Philippines, Slovakia, Taiwan, and Türkiye. Using a preregistered design, 993 university students were assessed with three perceptual tasks based on Navon's hierarchical figures and Gottschaldt's embedded figures. Analytic and holistic cognitive styles were estimated using reaction time modeling, specifically a Bayesian four-parameter shifted Wald distribution and a hierarchical linear ballistic accumulator model.

Geometric Reconstruction of Cartilage Tissue With Mesenchymal Stem Cell-Assisted Electromechanical Reshaping: An Experimental Study.

Shaping the ear cartilage and preserving the shape are important and quite difficult. The aim of this study was to demonstrate the effectiveness of the Wharton's jelly-derived stem cell-assisted electromechanical reshaping method in a rabbit ear cartilage defect model and to compare it with surgical reshaping.For the purpose of 25 × 4-mm cartilage defect reconstruction, 48 rabbit ears were divided into 2 main groups according to the shaping method, and these main groups were divided into 3 subgroups according to stem cell injection: control, sham, and stem cell.

Associations between stages of diabetic polyneuropathy and quality of life, neuropathic pain, and well-being: A multicenter, cross-sectional analysis based on electroneuromyographic findings.

Aim: This study aimed to investigate the relationship between electrophysiological findings of diabetic neuropathy (DN) and patients' quality of life, neuropathic pain levels, and well-being.

Materials And Methods: A cross-sectional study was conducted in 12 centers in Turkey. DN patients were categorized into four stages based on electrophysiological findings using the Baba classification.

Brucellosis Prevention Questionnaire (BPQ): Adaptation to Turkish Culture, Validity and Reliability Study.

Background: Brucellosis is the most common zoonosis worldwide. Prevention of brucellosis is based on surveillance and prevention of risk factors.

Aim: The aim of this methodological study, conducted with breeders living in Kütahya, was to perform the Turkish adaptation, validity and reliability study of the Brucellosis Prevention Questionnaire (BPQ).

Periradicular repair after single-visit root canal treatment using sonic irrigant activation of teeth with apical periodontitis.

Objectives: This study aimed to explore whether using sonic irrigant activation during endodontic treatment favors periradicular repair in teeth with apical periodontitis.

Materials & Methods: One clinician treated 140 posterior (either premolar or molar) asymptomatic teeth with periapical lesions: 70 were randomly assigned to the sonic activation with EndoActivator (EA) group, and 70 were treated by conventional needle irrigation (CNI). Both groups underwent chemomechanical root canal preparation using 35/04 diameter rotary files and 2.

Sorafenib vs chemotherapy in the treatment of locally advanced or metastatic, radioactive iodine-refractory differentiated thyroid cancer: real-world data from Turkey.

Managing locally advanced, or metastatic radioactive iodine-refractory differentiated thyroid cancers (RAIR-DTC) poses substantial challenges, with few available treatment options. The aim of this study was to evaluate clinical outcomes of patients receiving sorafenib as first line treatment. In addition, prognostic markers affecting progression-free survival (PFS) were identified.

Multimodal Neuroimaging in the Prediction of Deep TMS Response in OCD.

.Brain morphological biomarkers could contribute to understanding the treatment response in patients with obsessive-compulsive disorder (OCD). Multimodal neuroimaging addresses this issue by providing more comprehensive information regarding neural processes and structures.

Investigation of the playing digital games on shoulder flexibility, muscle strength and reaction speed in volleyball players.

Esports is a natural extension of digital games. Digital games provide a platform for players to showcase their skills, thereby forming the foundation of e-sports. These two domains continuously support each other, demonstrating significant growth in popularity and establishing a solid presence in the competitive landscape.

Efficacy of Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 Questionnaire in Assessing Alpha-blocker Treatment Response in Patients With Benign Prostatic Hyperplasia: A Prospective, Multicenter, Cohort Study.

Objective: To evaluate the efficacy of the symptoms of the Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire in assessing alpha-blocker treatment response in patients with lower urinary tract symptoms (LUTS).

Methods: This prospective, non-randomized, multicentre trial included males with LUTS who visited urology outpatient clinics between January and April 2023. The most employed LUTS questionnaire is the International Prostate Symptom Score (IPSS), while the LURN SI-29 was also utilized.

Evaluation of the Incidence and Stage of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Study.

Aim: This study aims to retrospectively evaluate the incidence and stage of oral mucositis in patients undergoing hematopoietic stem cell transplantation.

Methods: A total of 102 patient records of patients hospitalized between 2014 and 2019 in the adult hematopoietic stem cell transplantation clinic of a tertiary university hospital in Turkey were evaluated. Data were collected through a retrospective evaluation of patient records.

Enhancement of methane production by electrohydrolysis pretreatment for anaerobic digestion of OFMSW.

Hydrolysis is the most critical rate-limiting step in the anaerobic digestion (AD) process for most types of substrates. The organic fraction of municipal solid waste (OFMSW) is a rich source for the AD process because of its high degradability. In this study, electrohydrolysis pretreatment was investigated for the OFMSW to overcome the rate-limiting step of hydrolysis.

Construction of Protein Sequence Databases for Metaproteomics: A Review of the Current Tools and Databases.

In metaproteomics studies, constructing a reference protein sequence database that is both comprehensive and not overly large is critical for the peptide identification step. Therefore, the availability of well-curated reference databases and tools for custom database construction is essential to enhance the performance of metaproteomics analyses. In this review, we first provide an overview of metaproteomics by presenting a concise historical background, outlining a typical experimental and bioinformatics workflow, emphasizing the crucial step of constructing a protein sequence database for metaproteomics.

IDO1-mediated catabolism of tryptophan in gastric tumors: Its potential role in the axis of histopathology, differentiation and metastasis.

Background: Indoleamine 2,3-Dioxygenase 1 (IDO1)-mediated tryptophan degradation, which is the rate-limiting enzyme of tryptophan/kynurenine pathway, may cause immune suppression in the tumor microenvironment, while potentiating proliferative and metastatic activity in the tumor focus, Phase studies of IDO1 inhibitors are ongoing, and our study aims to evaluate the potential contribution of IDO1 gene expression to the tryptophan/kynurenine pathway in tumor and tumor microenvironment foci in gastric cancer (GC) on a clinicopathological axis, METHOD: In the case-control study design, the determination of tryptophan and its metabolites in the serum of 51 GC and 49 healthy controls was made using High Pressure Liquid Chromatography-Fluorescence Detector (HPLC-FD). IDO1 expression in a total of 102 tissues with tumor and tumor microenvironment was detected by quantitative PCR (q-PCR).

Results: In gastric tumors, 3,25-fold decreased expression of IDO1 was detected according to the tumor microenvironment (p=0,05), IDO1 expression was found to be more than 2 times higher in signet ring cell carcinoma (SRCC) and poorly differentiated tumors without distant organ metastasis (p<0,05), In GC, tryptophan level was found to be 1,6 times lower than in control (AUC:0889; cut off≤21,57; p<0001), Low tryptophan level was found in advanced tumor stage compared to early stage and in the presence of perineural invasion compared to its absence (p<0,05) The level of kynurenine was found to be approximately 1,8 times lower in SRCC (p=0,04), CONCLUSION: Increased tryptophan accumulation in the gastric tumor and its microenvironment, when catabolized via IDO1, exhibits histological type, tumor differentiation, and metastasis-promoting effects more prominently in aggressive subtypes such as SRCC.