Publications by authors named "Ozeretskovskiĭ N"

Modern data substantiating the expediency of the use of acellular pertussis vaccine were analyzed. Serious postvaccinal complications caused by the action of the corpuscular pertussis component of adsorbed DPT vaccine served as the basis for the development of acellular pertussis vaccine (APV). During the period of 1990-1996 as many as 8 international field trials of the effectiveness of APV were carried out.

View Article and Find Full Text PDF

Bubo-M, the first Russian combined vaccine, was found to have low reactogenicity. The difference between the number of postvaccinal reactions in the group of children immunized with Bubo-M (25.9%) and those in the group of children who had been simultaneously injected into different sites of the body with ADS-M toxoid (adsorbed DT toxoid with reduced antigen content) and hepatitis B vaccine (26.

View Article and Find Full Text PDF

Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%).

View Article and Find Full Text PDF

A safe, moderately reactogenic and immunologically effective scheme of complex (combined) immunization against meningitis A, diphtheria, typhoid fever, viral hepatitis A and influenza has been developed as the result of experimental and clinico-immunological studies. Depending on the epidemiological situation, the newly developed scheme can be used in two variants. According to the first variant of this scheme, the following preparations are injected subcutaneously into three different sites: a mixture of group A meningococcal vaccine and diphtheria toxoid, typhoid vaccine and influenza vaccine.

View Article and Find Full Text PDF

The influence of pertussis preparations, introduced by oral and parenteral routes, on the detoxifying function of the liver and the state of the nervous system of the animals was studied by methods used in pharmacology and toxicology. The use of these methods made it possible to find out side effects produced by corpuscular pertussis vaccine, introduced parenterally, on the detoxifying function of the liver and the state of the nervous system of the animals. The negative influence on the nervous system was more pronounced after the injection of the commercial adsorbed diphtheria-pertussis-tetanus vaccine used in this investigation than after the injection of pertussis monovaccine.

View Article and Find Full Text PDF

Analysis is made of the data obtained during clinical studies of the vaccinal process in 54 children with grades I-II thymus enlargement, vaccinated against measles. The clinical course of the vaccinal process in these children does not differ from the common course in normal children vaccinated against measles. The children with grades I-II thymus enlargement are capable of producing humoral antiviral immunity and of preserving high titres of antiviral antibodies for a long time.

View Article and Find Full Text PDF

Inhibition of cellular and humoral immunity was established in children with grade I thymus enlargement syndrome (TES). The most pronounced changes were recorded in children aged 1-5 years. Vaccination against diphtheria and tetanus performed before the diagnosis of the TES was made were followed by satisfactory output of anatoxins, indicating the prospectiveness of the vaccination of the given children's group with DPT vaccine and DT- and DT-M-anatoxin.

View Article and Find Full Text PDF

The results of 10-year virological and immunological studies in patients with postvaccination encephalitis (PVE) developing after smallpox vaccination are analysed. Vaccinia virus was isolated from 23 (59%) out of 39 children in the acute stage of PVE and for a long period in the protracted course of the disease in 14 out of 24 from the cerebrospinal fluid in 15 out of 33 from the blood, in 8 out of 24 from the throat and in 4 out of 5 from the brain or spinal cord tissue. Examinations of 56 serum specimens from 36 children with PVE revealed considerable variations in the levels of virus-neutralizing antibodies (VNA): 6 had no VNA, while 10 children showed low titres (10-20).

View Article and Find Full Text PDF

The possibility of using pharmacological tests to determine side effects produced by adsorbed DPT vaccine and chemical typhoid vaccine was studied. Both vaccines were shown to be capable of prolonging sleep induced by hexenal or thiopental in experimental animals. The following difference in the action of these two preparations was revealed on the model of "chemical convulsions" induced by the injection of thiosemicarbazide: while immunization with DPT vaccine acitivated thiosemicarbazide-induced convulsive syndrome in mice, no such stimulating effect was observed after the injection of typhoid, vaccine.

View Article and Find Full Text PDF

The experimental model of chemical convulsions allowed to establish the fact that the death of mice immunized with adsorbed DPT vaccine was accelerated, in comparison with the control group, as a result of convulsive fits caused by the injection of thiosemicarbazide. Immunization with adsorbed DPT vaccine was also found to induce a qualitative change in convulsive fits. The fact that an increase in convulsive activity occurs in the animals immunized with absorbed DPT vaccine may be related to the appearance of some forms of convulsive states in children during the postvaccination period.

View Article and Find Full Text PDF

A comparative study of smallpox vaccines prepared from the l-ivp zm-63 and b-51 strains was carried out under conditions of controlled epidemiological trial. Children subject to planned vaccination were scarified with commercial batches of the preparations under study (with the same infectious activity). As a result of investigations it was found that in the group of those scarified with the vaccine from zm-63 strain strong local and catarrhal reactions and some disturbances of general condition were more frequent than in those scarified with preparations from the l-ivp and b-51 strain.

View Article and Find Full Text PDF

Prophylactic activity and side action of antiinfluenza lactoglobulin were studied under conditions of controlled epidemiological trial in 6361 persons during the epidemiological rise of influenza incidence. The data obtained pointed to the absence of any protective effect of antiinfluenza lactoglobulin. Marked allergenic properties of lactoglobulin and development of sensitization in the persons under observation were found during the study of the side-effect of the preparation.

View Article and Find Full Text PDF