Interdisciplinary and Collaborative Training in Neuroscience: Insights from the Human Brain Project Education Programme.

Neuroscience education is challenged by rapidly evolving technology and the development of interdisciplinary approaches for brain research. The Human Brain Project (HBP) Education Programme aimed to address the need for interdisciplinary expertise in brain research by equipping a new generation of researchers with skills across neuroscience, medicine, and information technology. Over its ten year duration, the programme engaged over 1,300 experts and attracted more than 5,500 participants from various scientific disciplines in its blended learning curriculum, specialised schools and workshops, and events fostering dialogue among early-career researchers.

Molecular docking and dynamics simulation analysis of PDE5 inhibitor candidates for erectile dysfunction treatment.

Objective: Molecular docking studies were conducted to assess the binding affinities of five potential inhibitor candidates [PDB (Protein Data Bank) ID: 6L6E] against Phosphodiesterase 5 (PDE5), with Sildenafil used as the reference compound. The aim of this study is to reveal the potential inhibitory role of plant-derived compounds compared to Sildenafil, a PDE5 inhibitor.

Materials And Methods: Autodock Vina v.

Unique content of breastmilk: neurotrophic growth factors in breastmilk at 2 years and beyond.

The aim of our study was to show the presence of neurotrophic factors in breast milk that have a significant impact on neurocognitive development of children aged two years and beyond. Mothers expressed at least 5 mL of breast milk into sterile containers when their children 18, 24, and ≥ 25 months of age, and then specimens were transferred to Eppendorf tubes and stored at -20 °C. One day before the analysis, specimens were kept at +4 °C and then thawed at room temperature to prepare them for analysis.

Reliability and validity of the Turkish version of the 39-item Parkinson Disease Questionnaire.

Background And Purpose:

Vaccine Adherence and Postvaccination Serological Status of Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Single-center Experience.

Despite developing consensus guidelines addressing immunization after hematopoietic stem cell transplantation (HSCT), studies showed deviations from recommended immunization practices commonly occur. Difference between the ideal scenario presented in guidelines and real-life scenarios is one of the most recognized barriers to implementing recommended practices. Therefore, this study aimed to evaluate pediatric allogeneic HSCT recipients' adherence to revaccination schedule and evaluate the serological status after immunization.

A countrywide analysis of 27 solar power plants installed at different climates.

The world is still heavily using nonconventional energy sources, which are worryingly based on carbon. The step is now alternative energy sources hoping that they will be more environmentally friendly. One of the important energy conversion forms by using these sources is photovoltaic solar systems.

Solar irradiation on the rear surface of bifacial solar modules: a modeling approach.

The transition in the energy sector has started with the growing population leading to the growing energy demands. The use of photovoltaic (PV) technologies has become a crucial way to meet energy demand. There are many ongoing studies for increasing the efficiency of commercial PV modules.

Faecal calprotectin levels during the first year of life in healthy children.

Aim: A high faecal calprotectin (FC) level is a non-invasive marker for inflammatory bowel disease. Nevertheless, healthy infants have elevated levels of FC with large variations. The aim of our study was to determine the levels of FC and associated factors in healthy infants aged 0-12 months.

Evaluation of Chemical Composition and Biological Activities of Three Endemic Species from Anatolia ( and ).

In the present work we carried out a phytochemical and biological investigation on three endemic species, from Anatolia in order to discover new sources of natural compounds for the treatment of inflammatory and neurodegenerative disorders. HPLC-DAD analysis indicated that two naphthodianthrones (pseudohypericin and hypericin) together with chlorogenic acid, rutin, hyperoside, isoquercitrin, kaempferol, quercitrin, quercetin, amentoflavone, and hyperforin are the main compounds present in the methanol extracts. After chemical characterization, all extracts were in-vitro biologically assayed for antioxidant potential by lipid peroxidation inhibitory activity, DPPH, FRAP assays, and superoxide radical scavenging activity, for AChE inhibitory activity by Ellman's method, for COX inhibitory activity by using enzyme immunoassay (EIA) kit, for cytotoxic activity on HeLa and NRK-52E cell lines by MTT assay.

Results of a massive experiment on virtual currency endowments and money demand.

We use a 575,000-subject, 28-day experiment to investigate monetary policy in a virtual setting. The experiment tests the effect of virtual currency endowments on player retention and virtual currency demand. An increase in endowments of a virtual currency should lower the demand for the currency in the short run.

Lyapunov-type inequalities for quasilinear elliptic equations with Robin boundary condition.

The aim of this study is to prove Lyapunov-type inequalities for a quasilinear elliptic equation in [Formula: see text]. Also the lower bound for the first positive eigenvalue of the boundary value problem is obtained.

UHPLC-ESI-MS/MS and GC-MS Analyses on Phenolic, Fatty Acid and Essential Oil of with Antioxidant, Anticholinesterase, Antimicrobial and DNA Damage Protection Effects.

This paper is the first phytochemical and ABTS cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and DNA damage protection effect of endemic (Boiss.) O. Kuntze.

Copper, zinc and iron levels in infants and their mothers during the first year of life: a prospective study.

Background: Essential micronutrients are important for maintenance of life. Deficiency of micronutrients is more likely to be encountered in children, and women studies are required to investigate the status of micronutrients in children and women. This study aimed to longitudinally evaluate changes in zinc, copper, and iron levels in breastfed infants and their mothers during the first year of life.

Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study.

Background: We aimed to show the relationship between recurrence of wheezing and serum levels of vitamin D, zinc, and copper in wheezy children compared with a healthy group.

Methods: In this cross sectional study, seventy-three children with wheezing and seventy-five controls were included without a follow-up period. The clinical characteristics of the children were assessed, the asthma predictive index and temporal pattern of wheeze were determined.

Effect of maternal and infant vitamin D supplementation on vitamin D levels of breastfed infants.

The aim of our study was to investigate the effect of maternal vitamin D3 (400 U/day) supplementation on breastfed infants at 6 months of age. Mothers (n=96) were enrolled within 1 month after birth and assigned to the 400 IU/day regimen or no vitamin D3 supplementation for 6 months. All infants received 400 IU/day of vitamin D3 and were exclusively breastfed until 4 months of age.

Aortic stiffness and plasma brain natriuretic peptide predicts mortality in acute ischemic stroke.

Background: The study aimed to evaluate the prognostic role and discriminative power of aortic stiffness and plasma brain natriuretic peptide levels in a cohort of patients hospitalized for acute ischemic stroke.

Methods And Results: Three hundred and ten consecutive patients aged 50 years and older with a first episode of acute ischemic stroke were prospectively evaluated. All patients were admitted to the hospital within 24 h of the onset of stroke symptoms.

Are metabolic syndrome antecedents in prepubertal children associated with being born idiopathic large for gestational age?

Introduction: Being born large for gestational age (LGA) is a risk factor for development of metabolic syndrome (MS) in adolescents and adults.

Objective: To evaluate prepubertal children born idiopathic LGA to non-obese mothers without gestational diabetes or glucosuria with respect to the presence of MS antecedents.

Patients And Methods: We conducted a cross-sectional study to compare 40 (19 F) LGA-born prepubertal children of a mean age of 6.

Effect of iron supplementation on development of iron deficiency anemia in breastfed infants.

This trial aimed to investigate the effect of iron supplementation on the development of iron deficiency anemia. The study encompassed 6-month-old infants who had been exclusively breastfed in the first 4 months of life. Infants in the supplemented group were given 1 mg kg(-1 )day(-1) ferrous sulfate for 6 months starting at 6 months of age.

Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011.

In 2010, 47 human cases of West Nile virus (WNV)infection, including 12 laboratory-confirmed and 35 probable cases, were identified in Turkey. These were the first cases detected during routine surveillance.The patients were from 15 provinces, mainly located in the western part of the country.

Serum and hair zinc levels of infants and their mothers.

Objectives: This cross-sectional study aimed to investigate the zinc status of mothers and their infants attending a well-child clinic.

Methods: Blood and hair samples were collected from infants and their mothers at 2nd, 6th,12th month after delivery. Information on infant and their mothers' dietary habits was gathered.

Influence of vanadium supplementation on oxidative stress factors in the muscle of STZ-diabetic rats.

In recent years, the role of free radical damage consequent to oxidative stress is widely discussed in diabetic complications. In this aspect, the protection of cell integrity by trace elements is a topic to be investigated. Vanadium is a trace element believed to be important for normal cell function and development.

Effect of hypo-and euthyroid status on serum cystatin C levels.

Objective: The aim of this study was to investigate the effect of hypo- and euthyroid status on serum cystatin C (CysC) levels in children and to explore whether CysC can be used as a marker of the thyroid status.

Methods: Twenty five patients with hypothyroidism (10M, 15F; mean age:8.7±4.

Elevated hair levels of cadmium and lead in school children exposed to smoking and in highways near schools.

Objectives: Heavy metal pollution has become a serious health concern in recent years. Cadmium (Cd) and Lead (Pb) are toxic heavy metals. This study was aimed to determine the risk factors for high cadmium and lead levels in school children.

The effects of hyperbaric oxygen treatment on oxidant and antioxidants levels during liver regeneration in rats.

The effects of hyperbaric oxygen (HBO) therapy on oxidant/antioxidant metabolism are controversial and its effects on hepatic regeneration are not known. In this study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight Spraggue-Dawley rats and the rats were divided into two equal groups: HBO-treated group and untreated group (non-HBO group).

Relationship between plasma Cystatin C and creatinine in chronic renal diseases and Tx-transplant patients.

Objectives: Glomerular filtration rate (GFR) is the best overall index of renal function in health and disease. Recently, Cystatin C (Cyst C), a low molecular weight protein freely filtered through the glomerulus, and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in GFR. This study investigated the relationship between Cyst C and creatinine (CR) in renal disease patients.