Diagnostic Efficacy of Sputum Cytology versus Invasive Procedures for Lung Cancer: A Comparative Study.

Objective And Aim: Interventional diagnostic procedures such as bronchoscopy and transthoracic needle aspiration can lead to significant complications, especially in more vulnerable patients. In our study, we aimed to evaluate the characteristics of patients with high diagnostic rates via sputum cytology, a non-invasive technique.

Methods: This retrospective, nested case-control study included patients who were diagnosed with lung cancer and who underwent sputum cytology at least once in our tertiary referral hospital between 2012 and 2022.

Unraveling the Role of RSPRY1 in TGF-β Pathway Dysregulation: Insights into the Pathogenesis of Spondyloepimetaphyseal Dysplasia.

Skeletal dysplasias, characterized by bone, cartilage, and connective tissue abnormalities, often arise due to disruptions in extracellular matrix (ECM) dynamics and growth factor-dependent signaling pathways. RSPRY1, a secreted protein with RING and SPRY domains, has been implicated in bone development, yet its exact role remains to be determined. gene mutations are associated with spondyloepimetaphyseal dysplasia (SEMD), a rare skeletal disorder characterized by severe epiphyseal and metaphyseal deformities.

Detailed characterization of bone marrow adipose tissue mesenchymal stem cells in healthy donor, Fanconi anemia, and acute myeloid leukemia.

Bone marrow is a complex tissue featuring distinct cellular organization and diverse cell types. Bone marrow adipose tissue (BMAT) is a dynamic component crucial for tissue function and disease processes. This study explores differences between bone marrow-derived mesenchymal stem cells (BM-MSCs) and BMAT-derived mesenchymal stem cells (BMAT-MSCs), isolated from the same cavity, examining their differentiation potential and secretory profiles.

Technology-Based Interventions for Pain in Children Undergoing Surgery: A Systematic Review and Meta-Analysis.

Aim: This systematic review and meta-analysis aimed to evaluate the effect of technology-based interventions on the pain of paediatric surgery patients.

Background: Recently, the number of technology-based interventions involving multimodal nonpharmacological methods tailored to pain management in paediatric surgery patients has increased. It is crucial to determine the effectiveness of these interventions.

"The M-APNE score: an objective screening tool for OSA highlighting the area under the inspiratory flow-volume curve".

Background: Polysomnography (PSG) is resource-intensive but remains the gold standard for diagnosing Obstructive Sleep Apnea (OSA). We aimed to develop a screening tool to better allocate resources by identifying individuals at higher risk for OSA, overcoming limitations of current tools that may under-diagnose based on self-reported symptoms.

Methods: A total of 884 patients (490 diagnosed with OSA) were included, which was divided into the training, validation, and test sets.

Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage.

Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO) affects systemic anti-inflammatory response and inflammation.

Simple Isolation of Human Bone Marrow Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells.

Bone marrow adipose tissue (BMAT) has garnered significant attention due to its critical roles in leukemia pathogenesis, cancer metastasis, and bone marrow failure. BMAT is a metabolically active, distinct tissue that differs from other fat depots. Marrow adipocytes, closely interacting with hematopoietic stem/progenitor cells and osteoblasts, play a pivotal role in regulating their functions.

Use of radial endobronchial ultrasonography in the distinction between intraluminal and mixed type tracheal schwannoma: A case report.

Tracheal schwannomas are exceedingly rare, accounting for a minute fraction of primary tracheal tumors. They are classified into intraluminal and mixed types, with treatment strategies varying significantly between these subtypes. While thorax tomography is usually sufficient to distinguish intraluminal and mixed type, endobronchial ultrasonography (EBUS) can also be used in cases where the distinction cannot be made clearly with tomography.

GaAs nano-ridge laser diodes fully fabricated in a 300-mm CMOS pilot line.

Silicon photonics is a rapidly developing technology that promises to revolutionize the way we communicate, compute and sense the world. However, the lack of highly scalable, native complementary metal-oxide-semiconductor (CMOS)-integrated light sources is one of the main factors hampering its widespread adoption. Despite considerable progress in hybrid and heterogeneous integration of III-V light sources on silicon, monolithic integration by direct epitaxy of III-V materials remains the pinnacle of cost-effective on-chip light sources.

Association of Biopsy-proven Nonalcoholic Fatty Liver Disease with Obesity and Apolipoproteins.

Background And Aims: Insulin resistance is considered the most important key mechanism in the development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that hyperinsulinemia decreases the hepatic secretion of apolipoprotein (Apo) B. Chronic hyperinsulinemia in NAFLD may be responsible for the accumulation of triglycerides in hepatocytes.

Downregulation of MGLL and microRNAs (miR-302b-5p, miR-190a-3p, miR-450a-2-3p) in non-small cell lung cancer: potential roles in pathogenesis.

Genes involved in lipid metabolism have been considered potential therapeutic targets in lung cancer because lipid metabolism is severely disrupted in this cancer. Monoglyceride lipase (MGLL) is a lipolytic enzyme that converts monoacylglycerides to fatty acids and glycerol. MicroRNAs (miRNA), one of the most important epigenetic regulators of gene expression, are also considered potential biomarkers in diagnosing, treating, and prognosis lung cancer.

A Dynamic Model for Early Prediction of Alzheimer's Disease by Leveraging Graph Convolutional Networks and Tensor Algebra.

Alzheimer's disease (AD) is a neurocognitive disorder that deteriorates memory and impairs cognitive functions. Mild Cognitive Impairment (MCI) is generally considered as an intermediate phase between normal cognitive aging and more severe conditions such as AD. Although not all individuals with MCI will develop AD, they are at an increased risk of developing AD.

Abscopal effect-induced spontaneous regression of distant metastases in malignant mesenchymal tumor: a case report.

The abscopal effect refers to an anti-tumor response that occurs in areas where radiotherapy (RT) has not been directly administered but is triggered by the immune system. We presented a case of an undifferentiated pleomorphic sarcoma with three relapses that showed a complete response after distant metastatic disease. The tumor was initially detected in the left pectoral muscle.

Clinical and prognostic effects of microvascular density and FOXP3 positive T cells in breast cancer.

There are conflicting data regarding the prognostic effect of microvascular density (MVD) in breast cancer and its molecular subtypes. It is thought that high levels of FOXP3 + T cells in breast cancer are associated with poor prognosis. However, data regarding FOXP3 show significant variability in the literature.

Developing an instrument to measure nurses' attitudes towards nursing students during clinical practice: A quantitative study.

Background: Since nursing students' interactions with nurses in the clinical practice process play an important role in nursing education and practice, it is a necessity to evaluate nurses' attitudes towards students.

Aim: To develop a valid and reliable measurement tool to determine the attitudes of nurses' towards nursing students in the clinical practice process.

Design: This study used a quantitative cross-sectional design.

Comparative analysis of biofilm structures in Salmonella Typhimurium DMC4 strain and its dam and seqA gene mutants using Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy methods.

It is well-established that the dam and seqA genes act in the biofilm production in Salmonella. However, the molecular basis underlying this activity remains unexplored. This study aims to address this gap in the literature.

Genetic Variations and Serum Levels of Leptin and Ghrelin in Autism Spectrum Disorder.

Background: This study aims to examine leptin and ghrelin gene polymorphisms and serum levels in children with autism spectrum disorder (ASD).

Methods: The study comprised a case group of 40 children aged 2-7 diagnosed with ASD and a control group of 40 healthy children. The severity of ASD symptoms was assessed using the Childhood Autism Rating Scale and the Autism Behavior Checklist.

Pain, Physical Activity, Kinesiophobia, Balance and Fall Risk in Patients with Diabetic Neuropathy.

Purpose: In this study, we aimed to investigate the risk of balance disorders and falls in patients with diabetic neuropathic pain and the associated kinesiophobia and physical limitation.

Methods: This study was designed as a cross-sectional descriptive study and was conducted with 250 patients seen in Family Medicine outpatient clinics between February and March 2023. The Tampa Kinesiophobia Scale (TSK) was used to measure the patients' fear of movement/reinjury, the International Fall Efficacy Scale (FES-I) was used to measure the level of fear of falling, the Berg Balance Scale (BBS) was used to assess balance status, and the International Physical Activity Questionnaire (IPAQ) was used to assess all activities during the day.

Respiratory responses and isocapnic buffering phase in child and youth soccer players during an incremental exercise test.

Purpose: This study investigated the respiratory response and isocapnic buffering (IB) phase during an incremental exercise test to exhaustion in 16 child soccer players (11.9±0.9 years) and 18 youth soccer players (18.

The epithelial barrier theory and its associated diseases.

The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory came to light explaining the growing prevalence and exacerbations of these diseases worldwide.

Effect of hemoglobin, albumin, lymphocyte, and platelet score on prognosis in intermediate-risk endometrial cancer according to molecular-based classification.

Objective: The aim of this study is to compare the relationship between molecular classification and HALP score in endometrial cancer (EC).

Methods: Patients who were operated with the diagnosis of EC 2014 and 2024 were included in our study. 150 patients were included in the study.