Morphological changes of trabeculectomy specimens in different kinds of uveitic glaucoma.

Purpose: To analyze morphological changes in trabeculectomy specimens of patients suffering from uveitic secondary open angle glaucoma (UG).

Material And Methods: Trabeculectomy specimens of six patients suffering from uveitis for 2 to 19 years and having been treated with steroids for 5 to 86 months were obtained during antiglaucomatous surgery after failed antiglaucomatous drug treatment. Six specimens, four from patients with Fuchs' heterochromic cyclitis (FHC), one with Herpes simplex-associated uveitis (HS), and one with juvenile idiopathic arthritis-associated uveitis (JIA) were analyzed by light and electron microscopy.

Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG.

Purpose: To analyze the vasculature and extracellular matrix changes in the prelaminar region (PreLR) of the optic nerve head (ONH) and in the peripapillary sclera of eyes with primary open-angle glaucoma (POAG) and age-matched control eyes.

Methods: In histologic sagittal sections of 46 eyes with POAG and 45 control eyes (donor ages, 20-96 years), the peripapillary sclera and penetrating vessels were investigated ultrastructurally and with antibodies against elastin, podocalyxin, and α-actin. Within the PreLR, the number and density of capillaries and the thickness of their connective tissue sheaths (CTSs) were quantified.