Publications by authors named "Ozan Topcu"

Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational modification attenuates sensitivity of RAS towards RAF. As such, in this study, we set out to unveil the impact of phosphorylation on dynamics of HRAS and aim to invoke similar behavior in HRAS mutant by means of small therapeutic molecules.

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