Comparison of the effects of dexmedetomidine administered at two different times on renal ischemia/reperfusion injury in rats.

Background And Objectives: We investigated the effect of dexmedetomidine on ischemic renal failure in rats.

Methods: In the present study, 26 male adult Wistar albino rats weighting 230-300 g were randomly separated into four groups: sham-operated (n=5), ischemia reperfusion (IR) (IR group, n=7), IR/reperfusion treatment with dexmedetomidine (Dex. R group, n=7) and IR/pre-ischemic treatment with dexmedetomidine (Dex.