Publications by authors named "Oyelese Y"

Despite its critical importance, the placenta receives substantially less attention during obstetric ultrasound examinations compared to the fetus. The evaluation of the placenta is typically limited to determining its location within the uterus, particularly its relationship to the cervix. Abnormal placenta findings are the result of gross anomalies identified by chance during obstetric examinations, rather than from a systematic evaluation.

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Article Synopsis
  • Vasa previa (VP) is a serious complication where fetal blood vessels are vulnerable near the cervix, requiring cesarean delivery before labor to avoid severe risks.
  • Different obstetric organizations have varying guidelines on managing VP, especially regarding hospitalization, steroid use, and delivery timing for asymptomatic patients.
  • Current guidelines lack robustness, relying on low-quality evidence and not incorporating new research insights, highlighting the need for more substantial evidence for improved management strategies.
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Placenta Previa.

Clin Obstet Gynecol

March 2025

Article Synopsis
  • Placenta previa is a significant cause of bleeding during pregnancy and used to be a major cause of maternal deaths, but advancements in care have improved outcomes.
  • It is usually detected during routine ultrasounds in the second trimester, and most cases resolve before the due date.
  • Key risk factors include previous cesarean deliveries, older age, and smoking, and if the condition persists late in pregnancy, a cesarean delivery is advised.
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Article Synopsis
  • The symposium presents a series of reviews focused on important clinical aspects of the placenta and umbilical cord, covering conditions like placenta previa and abruption, as well as various pathologies and infections.
  • It highlights the critical functions of the umbilical cord as a lifeline for the fetus, discussing how its dysfunction can lead to complications such as vasa previa.
  • This collection emphasizes the significance of understanding these structures for ensuring maternal-fetal health throughout pregnancy.
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  • Postpartum depression (PPD) is a serious condition impacting both mothers and children, making it essential to study trends and risk factors related to its prevalence.
  • A recent study analyzed over 442,000 pregnancies from Kaiser Permanente Southern California between 2010 and 2021, examining the relationship between PPD and factors like race, ethnicity, and prepregnancy body mass index (BMI).
  • Results showed that PPD rates doubled from 9.4% in 2010 to 19.0% in 2021, with the highest increases among Asian/Pacific Islander and non-Hispanic Black populations, and worsening rates were particularly noted in individuals with obesity.
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"" This maxim underscores the importance of historical awareness in medicine, particularly for obstetricians and gynecologists (ObGyns). ObGyns significantly impact societal health through their care for pregnant women, fetuses, and newborns, uniquely positioning them to advocate for health initiatives with lasting societal benefits. Despite its importance, the history of medicine is underrepresented in medical curricula, missing opportunities to foster critical thinking and ethical decision-making.

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Objectives: To estimate the number of pregnancies complicated by vasa previa annually in nine developed countries, and the potential preventable stillbirths associated with undiagnosed cases. We also assessed the potential impact of universal screening for vasa previa on reducing stillbirth rates.

Methods: We utilized nationally-reported birth and stillbirth data from public databases in the United States, United Kingdom, Canada, Germany, Ireland, Greece, Sweden, Portugal, and Australia.

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Vasa previa is a condition where unprotected fetal vessels cross the cervix within the membranes, posing a considerable risk of fetal death or severe morbidity if the membranes rupture before or during delivery. There has not been a definitive treatment for this condition. Patients are typically closely monitored and hospitalized in the early third trimester and scheduled for cesarean delivery before term.

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Article Synopsis
  • Nicolaides-Baraitser syndrome (NCBRS) is a rare genetic condition leading to severe intellectual disabilities and other physical symptoms, diagnosed through clinical signs and the presence of a SMARCA2 mutation.
  • The case presented involves a prenatal diagnosis of caudal regression and congenital vertical talus, ultimately linked to a de novo SMARCA2 variant after the pregnancy was terminated.
  • This study suggests that these specific physical traits should be recognized as part of the spectrum associated with NCBRS when linked to the SMARCA2 pathogenic variant.
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Congenital anomalies of the umbilical cord are associated with an increased risk of pregnancy and perinatal complications. Some anomalies of the cord have a higher prevalence than other fetal structural anomalies. The most common anomalies are the absence of an umbilical artery and velamentous insertion of the cord (with or without vasa previa).

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Recent advances in genetics and imaging have ushered substantial breakthroughs in screening and diagnosis for chromosomal and structural abnormalities. Thus, it is imperative that health care providers caring for pregnant individuals should reexamine established practices in prenatal screening and diagnosis. In the past, screening for chromosomal abnormalities was based almost entirely on Down syndrome.

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Objective: The incidence of preterm delivery is much higher in twin pregnancies than in singletons and even higher if a short cervical length is detected in the second trimester. Studies are contradictory regarding the efficacy of a cervical pessary to decrease preterm birth in twin pregnancies and short cervical length. To conduct a systematic review and meta-analysis investigating the efficacy of cervical pessary in prolonging gestation, preventing preterm birth, and reducing adverse neonatal outcomes in twin pregnancies with an asymptomatic short cervix.

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Introduction: Vasa previa (VP), defined as unprotected fetal vessels traversing the membranes over the cervix, is associated with a high perinatal mortality when undiagnosed prenatally. Conversely, prenatal diagnosis with ultrasound and cesarean delivery before the membranes rupture is associated with excellent outcomes. However, controversy exists regarding screening for VP.

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Article Synopsis
  • The study examines the link between prenatal SARS-CoV-2 infection and adverse outcomes in pregnancy, focusing on how these associations differ by race/ethnicity.
  • During the study period, 7% of pregnant women tested positive for COVID-19, with the highest rates in Hispanic and non-Hispanic Black populations.
  • Results showed that Hispanic mothers had higher odds of adverse outcomes like nonreassuring fetal heart rate tracing, and various racial/ethnic groups faced different risks for ICU admissions after testing positive.
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Background: There are limited data to guide the diagnosis and management of vasa previa. Currently, what is known is largely based on case reports or series and cohort studies.

Objective: This study aimed to systematically collect and classify expert opinions and achieve consensus on the diagnosis and clinical management of vasa previa using focus group discussions and a Delphi technique.

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Objective: To evaluate trends of attention-deficit/hyperactivity disorder (ADHD) diagnosis rates among children aged 5-17 years over the past decade (2010-2021) and to investigate whether there have been differences in temporal changes based on race and ethnicity, sex, or income.

Study Design: Childhood ADHD diagnosis was ascertained from electronic health records using International Classification of Diseases ninth revision (314.xx) and International Classification of Diseases tenth revision (F90.

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Aim: To estimate the incidence of abruption in first births and recurrence in the subsequent birth in patients of a large US-based integrated health care system.

Methods: Retrospective population-based cohort study of patients with first two consecutive singleton births using data from the Kaiser-Permanente South California health care system who delivered over a period of 30 years (1991-2021), using longitudinally linked electronic health records. ICD-9/ICD-10 codes "641.

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Randomized controlled trials are considered the "gold standard" for therapeutic interventions, and it is not uncommon for sweeping changes in medical practice to follow positive results from such trials. However, randomized controlled trials are not without their limitations. Physicians frequently view randomized controlled trials as infallible, whereas they tend to dismiss evidence derived from sources other than randomized controlled trials as less credible or reliable.

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