Discovery of essential kinetoplastid-insect adhesion proteins and their function in Leishmania-sand fly interactions.

Leishmania species, members of the kinetoplastid parasites, cause leishmaniasis, a neglected tropical disease, in millions of people worldwide. Leishmania has a complex life cycle with multiple developmental forms, as it cycles between a sand fly vector and a mammalian host; understanding their life cycle is critical to understanding disease spread. One of the key life cycle stages is the haptomonad form, which attaches to insect tissues through its flagellum.

Molecular detection of Leishmania donovani, Leishmania major, and Trypanosoma species in Sergentomyia squamipleuris sand flies from a visceral leishmaniasis focus in Merti sub-County, eastern Kenya.

Background: Visceral leishmaniasis (VL) and zoonotic cutaneous leishmaniasis (ZCL) are of public health concern in Merti sub-County, Kenya, but epidemiological data on transmission, vector abundance, distribution, and reservoir hosts remain limited. To better understand the disease and inform control measures to reduce transmission, we investigated the abundance and distribution of sand fly species responsible for Leishmania transmission in the sub-County and their blood-meal hosts.

Methods: We conducted an entomological survey in five villages with reported cases of VL in Merti sub-County, Kenya, using CDC miniature light traps and castor oil sticky papers.

Understanding vulnerability and resilience in Somalia.

In the recent years, Somalia witnessed a heightened frequency of droughts and conflicts. This article explores the experiences of Somalis during the 2011 and 2016 crises, examining the link between vulnerability and resilience, and the role played by international humanitarian responders in resilience building. The aim of this study is to provide information on how different population groups responded to and managed to survive recurrent shocks; the prevailing drivers of marginalisation and exclusion, and mechanisms through which these are maintained; and the role of external stakeholders.

Necrotizing Fasciitis: A Predictable Burden in Rural Kenya.

Background: Necrotizing fasciitis (NF) is a devastating disease with substantial morbidity and mortality. Poor outcomes are attributed to delayed diagnosis and management. Tenwek Hospital, a teaching and referral center in rural Kenya, manages many cases despite variable resources.

Association of Phlebotomus guggisbergi with Leishmania major and Leishmania tropica in a complex transmission setting for cutaneous leishmaniasis in Gilgil, Nakuru county, Kenya.

Background: Phlebotomus (Larroussius) guggisbergi is among the confirmed vectors for cutaneous leishmaniasis (CL) transmission in Kenya. This scarring and stigmatizing form of leishmaniasis accounts for over one million annual cases worldwide. Most recent CL epidemics in Kenya have been reported in Gilgil, Nakuru County, where the disease has become a public health issue.

Strengthening Acute Flaccid Paralysis Surveillance Through the Village Polio Volunteers Program in Somalia.

Background: Surveillance for cases of acute flaccid paralysis (AFP) is a key strategy adopted for the eradication of polio. Detection of poliovirus circulation is often predicated on the ability to identify AFP cases and test their stool specimens for poliovirus infection in a timely manner. The Village Polio Volunteers (VPV) program was established in 2013 in a bid to strengthen polio eradication activities in Somalia, including AFP surveillance, given the country's vulnerability to polio outbreaks.

Is repeat use of emergency contraception common among pharmacy clients? Evidence from Kenya.

Background: As emergency contraception (EC) becomes more widely available in African pharmacies, public concern in many countries has emerged over perceived "repeat use" of the method. This study examines issues of repeat use in Kenya, a country where women almost exclusively obtain EC from pharmacies.

Study Design: Interviews were conducted with all clients who purchased EC from private pharmacies located in five urban areas across Kenya.

Socio-demographic and clinical aspects of rheumatoid arthritis.

Objective: To determine the socio-demographic profiles and some clinical aspects of patients with rheumatoid arthritis (RA).

Design: Prospective, cross-sectional study.

Setting: Ambulatory out- patient clinics of Kenyatta National Hospital (KNH), a public national and referral hospital.