Publications by authors named "Owen M Thomas"

Article Synopsis
  • The study examines the safety of radiation treatment for benign tumors in patients with NF2-related schwannomatosis, finding an increased risk of subsequent malignancies or malignant progression in those who received radiation compared to untreated patients.
  • Out of 1345 NF2 patients studied, 266 received radiation, leading to a malignancy rate of approximately 6%, as opposed to less than 1% in those not treated with radiation.
  • The findings suggest that NF2 patients should not receive radiation as the first treatment option for benign tumors due to the associated risks and should be informed about the significant risk of developing new malignancies.
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Objective: Many patients with cochlear implants (CI) and auditory brainstem implants (ABI) require magnetic resonance imaging (MRI) following implantation. This study explores the patient experience of MRI, identifying factors associated with pain, and the effect of interventions designed to enhance comfort and safety.

Methods: A prospective observational case series from a tertiary referral unit.

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Background: Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design.

Methods: A prospective database of patients meeting NF2 diagnostic criteria, reviewed between 1990 and 2020, was evaluated. Follow-up to first vestibular schwannoma (VS) intervention and death was assessed by univariate analysis and stratified by age at onset, era referred, and inheritance type.

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Article Synopsis
  • The study examined the occurrence of malignant peripheral nerve sheath tumors (MPNST) in patients with neurofibromatosis type 2 (NF2) using a database of 1253 NF2 patients.
  • Despite analyzing over 2000 cases of vestibular schwannomas, no spontaneous MPNST cases were found in unirradiated patients, although two patients developed MPNST after radiation treatment.
  • The conclusion indicates that NF2 patients should not be considered at heightened risk for malignant transformation of vestibular schwannomas unless they have received stereotactic radiosurgery, highlighting the need for larger studies to explore this potential link more thoroughly.
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Background: The Manchester criteria for neurofibromatosis type 2 (NF2) include a range of tumors, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas.

Objective: To determine whether these gliomas include any cases of malignant glioma (WHO grade III and IV) through a database review.

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In this paper we report the set-up and results of the Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized in conjunction with the MICCAI 2012 and 2013 conferences. Twenty state-of-the-art tumor segmentation algorithms were applied to a set of 65 multi-contrast MR scans of low- and high-grade glioma patients-manually annotated by up to four raters-and to 65 comparable scans generated using tumor image simulation software. Quantitative evaluations revealed considerable disagreement between the human raters in segmenting various tumor sub-regions (Dice scores in the range 74%-85%), illustrating the difficulty of this task.

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The impact of calcification on the carotid atherosclerotic plaque vulnerability remains controversial and unclear. This study assesses the critical mechanical conditions induced by the calcium at the lumen surface, i.e.

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Loss of shape recognition in visual-form agnosia occurs without equivalent losses in the use of vision to guide actions, providing support for the hypothesis of two visual systems (for "perception" and "action"). The human individual DF received a toxic exposure to carbon monoxide some years ago, which resulted in a persisting visual-form agnosia that has been extensively characterized at the behavioral level. We conducted a detailed high-resolution MRI study of DF's cortex, combining structural and functional measurements.

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Luminal stenosis is used for selecting the optimal management strategy for patients with carotid artery disease. The aim of this study is to evaluate the reproducibility of carotid stenosis quantification using manual and automated segmentation methods using submillimeter through-plane resolution Multi-Detector CT angiography (MDCTA). 35 patients having carotid artery disease with >30 % luminal stenosis as identified by carotid duplex imaging underwent contrast enhanced MDCTA.

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