Publications by authors named "Owen F Hale"
The rate, spectrum, and biases of mutations represent a fundamental force shaping biological evolution. Convention often attributes oxidative DNA damage as a major driver of spontaneous mutations. Yet, despite the contribution of oxygen to mutagenesis and the ecological, industrial, and biomedical importance of anaerobic organisms, relatively little is known about the mutation rates and spectra of anaerobic species.
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- - M. tuberculosis relies on heme as both a crucial nutrient and a source of iron for its survival and ability to cause disease, but heme can also be toxic.
- - The research reveals that M. tuberculosis prefers using heme it synthesizes internally over heme obtained from outside sources, suggesting a complex regulatory system for heme production and uptake.
- - Targeting the unique heme biosynthetic pathway may provide a new therapeutic approach for treating tuberculosis, especially since inhibiting heme synthesis does not trigger known heme import mechanisms.