Publications by authors named "Owen Bowie"
Article Synopsis
- The study investigates how the timing of hibernation affects retinal damage in 13-lined ground squirrels after injecting them with adenosine triphosphate (ATP).
- Eighteen squirrels were divided into three groups based on the season (early, mid, late) and underwent imaging before and after ATP injection to assess retinal health.
- Results indicated that early-season squirrels were more likely to suffer retinal damage, and further research is suggested to refine ATP dosing based on seasonal ocular changes.
Animal models of retinal degeneration are critical for understanding disease and testing potential therapies. Inducing degeneration commonly involves the administration of chemicals that kill photoreceptors by disrupting metabolic pathways, signaling pathways, or protein synthesis. While chemically induced degeneration has been demonstrated in a variety of animals (mice, rats, rabbits, felines, 13-lined ground squirrels (13-LGS), pigs, chicks), few studies have used noninvasive high-resolution retinal imaging to monitor the cellular effects.
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- The study focuses on improving health outcomes by addressing social determinants of health (SDOH) for uninsured individuals at a student-run free clinic in Milwaukee.
- Researchers screened 238 uninsured adult patients to identify SDOH needs and their access to dental and mental health care, finding significant correlations between these needs.
- The findings indicate that understanding SDOH needs can enhance resource offerings and interventions, ultimately leading to better support for under-resourced patients.
Several retinal degenerations affect the human central retina, which is primarily comprised of cones and is essential for high acuity and color vision. Transplanting cone photoreceptors is a promising strategy to replace degenerated cones in this region. Although this approach has been investigated in a handful of animal models, commonly used rodent models lack a cone-rich region and larger models can be expensive and inaccessible, impeding the translation of therapies.
View Article and Find Full Text PDFEvidence-based cognitive behavioral therapy for eating disorders includes a component of exposure therapy, which involves patients confronting feared eating and body-related stimuli while preventing safety behaviors. With recent research demonstrating that eating-related fears and safety behaviors are central to eating disorder pathology, there is increased emphasis on improving the efficacy of exposure therapy in eating disorders. Doing so will require a better understanding of important mechanisms of action in this treatment.
View Article and Find Full Text PDFPatient Barriers for Weight Management Among African American Women.
J Patient Cent Res Rev
October 2018
Article Synopsis
- - The study aimed to explore the perceptions of local African American women who are overweight or obese regarding barriers to weight management and to suggest tailored interventions for this group in Milwaukee.
- - Researchers conducted three focus groups with 41 participants, identifying key barriers such as food choices, lifestyle changes, social support, locus of control, and health education through qualitative analysis.
- - Conclusions emphasized the importance of community involvement in creating effective weight management strategies, recommending further research that includes other stakeholders like community leaders and healthcare providers.
Purpose: To describe and validate a semi-automated targeted sampling (SATS) method for quantifying optic nerve axons in a feline glaucoma model.
Methods: Optic nerve cross sections were obtained from 15 cats, nine with mild to severe glaucoma and six with normal eyes. Optic nerves were dissected, fixed in paraformaldehyde and glutaraldehyde, and processed for light microscopy by resin embedding, sectioning, and staining of axon myelin sheaths with 1% p-phenylenediamine before axon quantification.