Gastric neuroendocrine carcinoma after long-term use of proton pump inhibitor.

We present a case of a gastric neuroendocrine carcinoma in a patient with a history of long-term proton pump inhibitor (PPI) use. A 49-year-old man using PPI for the last 15 years due to gastroesophageal reflux disease developed progressive dysphagia, dyspepsia and weight loss. Upper gastrointestinal endoscopy, endoscopic ultrasonography and abdominal CT diagnosed a malignant tumor localized to a hiatal hernia.

Gastronet survey on the use of one- or two-person technique for colonoscopy insertion.

Background: Usually, colonoscopy insertion is performed by the colonoscopist (one-person technique). Quite common in the early days of endoscopy, the assisting nurse is now only rarely doing the insertion (two-person technique). Using the Norwegian national endoscopy quality assurance (QA) programme, Gastronet, we wanted to explore the extent of two-person technique practice and look into possible differences in performance and QA output measures.

What causes treatment failure - the patient, primary care, secondary care or inadequate interaction in the health services?

Background: Optimal treatment gives complete relief of symptoms of many disorders. But even if such treatment is available, some patients have persisting complaints. One disorder, from which the patients should achieve complete relief of symptoms with medical or surgical treatment, is gastroesophageal reflux disease (GERD).

Inflammatory bowel disease associated with Yersinia enterocolitica O:3 infection.

BACKGROUND: Certain microorganisms may be associated with the development of inflammatory bowel disease (IBD). These pathogens may possess such properties as immunological capability or tissue invasiveness. An association between Yersinia enterocolitica infection and ulcerative colitis (UC) was suggested 30 years ago, and a connection with Crohn's disease (CD) may also exist.

The effect of Helicobacter pylori retreatment with ranitidine bismuth citrate, clarithromycin, and metronidazole depends on the first-line therapy.

Background: Helicobacter pylori eradication rates seem to decrease. This study evaluates the effect of retreatment with ranitidine bismuth citrate (RBC) 400 mg B.I.