[Surgical treatment of acquired defects and ruptures of interventricular septum].

Surgical repair of posttraumatic ventricular septal defects, aortic-right ventricular fistulas and postinfarction ruptures of interventricular septum was carried out in 15 patients aged 18-75 years. Methods of radical correction included suturing, plastic repair with synthetic and autopericardial patches, and amputation of cardiac apex. Procedures were performed 14 days - 12 months after myocardial infarction and 1-12 months after penetrating knife wounds of the chest and the heart.

Antiradiation properties of alpha tocopherol, anthocyans, and pyracetam administered combined as a pretreatment course.

The effects of an pretreatment course (2 x 5 days) combining vitamin E 20 mg/kg, anthocyans 50 mg/kg, and pyracetam 200 mg/kg on animal survival after lethal irradiation (8 Gy) and blood formation after sublethal irradiation (6 Gy) were studied in mice. Assessments were based on records of an integral criterion, 30-day survival, of spleen weight and cellularity, and of bone-marrow cellularity. Pretreatment with the mixture distinctly raised survival rate (50%) in the protected population.

[A modification of the toxic effects of platinum complexes with antocyans].

The toxic and antitumor properties of biocysplantinum (cis-diaminodichlo-platinum) as well as a new platinum complex with acetic acid after their single and combined usage with antocyanes were studied on healthy mice and mice with transplanted ascitic tumour of Ehrlich. There was a reduction in total toxicity of biocysplatinum after simultaneous administration with antocyanes (300 mg/kg per os). Protective effect of antocyanes was observed on leukocytopoiesis.

[ECG spectral analysis in quick death, during clinical death, and in the early postresuscitation period].

The article deals with the results of ECG amplitude-frequency analysis conducted in 17 experiments on dogs in the process of quick death, clinical death, and early postresuscitation period. In group 1 (8 animals) circulatory arrest occurred after ventricular fibrillation, in group 2 (9 animals) clinical death was induced by acute blood loss. The ECG was recorded in 3 orthogonal leads after Frank.

[Importance of endogenous opioids and prostaglandins in the action of analgin (metamizole) and verapamil].

The effects of a non-narcotic analgetic methamizole and the calcium channel blocker verapamil on carrageenan hyperalgesia, release of beta-endorphin and synthesis of prostaglandin E2 (PGE2) were studied. It was found that a combined administration of analgin and verapamil prolonged the analgesic effect. Analgin stimulated release of beta-endorphin with the maximum coinciding in time with the peak of the analgesic effect.

[Inhibition of morphine hyperthermia, induced by nicotinamide].

The effect of nicotinamide, administered immediately before the morphine or on the background of already developed morphine hyperthermic reaction, was studied on morphine hyperthermia. It was established that nicotinamide, administered before morphine, inhibited development of morphine hyperthermia, statistically significantly up to 120 min after administration of morphine. Nicotinamide, administered, on the 60th min after morphine injection, did not inhibit significantly the developed already hyperthermic reaction.

Effects of compound IS-35 on intraocular pressure.

The influence of compound IS-35 on intraocular pressure of unanesthetized rabbits was studied. In some cases intraocular pressure was measured with either the tonometer of Schiotz and was calculated in mmHg according to Leydhecker's scale (1973), or with the tonometer of Maclakov. Intraocular pressure was measured before and at 30, 60, 120, 180, 240 and 360 min after topical application of IS-35, timolol and trimetoquinol.

Effect of diazepam and medazepam on prolactin secretion.

Pharmacological studies of the effect of Diazepam and Medazepam on prolactin secretion were carried out on sexually mature male albino rats. The experiments were carried out using two series of experimental set-ups. In the first series an analysis was made of the effect of Diazepam in doses of 2 and 4 mg/kg body mass, and of Medazepam in doses of 1 and 10 mg/kg body mass, on the prolactin secretion on the 60th min after a single intraperitoneal injection.

[Effect of GABA-ergic substances on the elaboration of conditioned reflexes in rats under negative reinforcement].

Experiments on female rats have shown that gabalid (100 and 200 mg/kg) does not essentially change the formation of the conditioned reflexes in intact animals and in those with an involved caudate nucleus whereas cainic acid injected intraperitoneally (15 mg/kg) and applied to the caudate nucleus deteriorates and when given in a dose of 5 mg/kg improves the formation of the conditioned reflexes. Baclofen (10 mg/kg) inhibits the conditioned reflexes in both intact animals and in those with an involved caudate nucleus, whereas in a dose of 1 mg/kg the drug improves it in intact animals and inhibits it in animals with impaired function of the caudate nucleus. The importance of the GABA-ergic system of the caudate nucleus for the action of GABA-ergic agents on the conditioned reflexes in rats is discussed.