Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.

Parkinson's disease (PD) is the second most common neurodegenerative disease and although many studies have been done on this disease, the underlying mechanisms are still poorly understood and further studies are warranted. Therefore, this study identified circRNA expression profiles in the cerebral cortex (CC), hippocampus (HP), striatum (ST), and cerebellum (CB) regions of the 1-methyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model using RNA sequencing (RNA-seq), and differentially expressed circRNA were validated using reverse transcription quantitative real-time PCR (qRT-PCR). Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and competing endogenous RNA (ceRNA) network analyses were also performed to explore the potential function of circRNAs.

Coupling Magnetic Single-Crystal Co Mo O with Ultrathin Nitrogen-Rich Carbon Layer for Oxygen Evolution Reaction.

Transition-metal oxides as electrocatalysts for the oxygen evolution reaction (OER) provide a promising route to face the energy and environmental crisis issues. Although palmeirite oxide A Mo O as OER catalyst has been explored, the correlation between its active sites (tetrahedral or octahedral) and OER performance has been elusive. Now, magnetic Co Mo O @NC-800 composed of highly crystallized Co Mo O nanosheets and ultrathin N-rich carbon layer is shown to be an efficient OER catalyst.

Nanostructures for Electrocatalytic CO Reduction.

One of the most effective ways to cope with the problems of global warming and the energy shortage crisis is to develop renewable and clean energy sources. To achieve a carbon-neutral energy cycle, advanced carbon sequestration technologies are urgently needed, but because CO is a thermodynamically stable molecule with the highest carbon valence state of +4, this process faces many challenges. In recent years, electrochemical CO reduction has become a promising approach to fix and convert CO into high-value-added fuels and chemical feedstock.

Clinical Characteristics, Surgical Outcomes, and Prognostic Factors of Intracranial Primary Central Nervous System Lymphoma.

Background: Intracranial primary central nervous system lymphoma (PCNSL) is a rare aggressive malignant tumor with poor prognosis. The effect of surgical resection on intracranial PCNSL is still controversial. This study investigates the efficacy and safety of surgical resection, as well as to analyze the clinical characteristics and prognostic factors of intracranial PCNSL.

Magnetic response of Arsenic pollution in a slag covered soil profile close to an abandoned tungsten mine, southern China.

Previous studies indicated serious soil arsenic (As) pollution of large spatial extent related to tungsten mining. We performed systematic analyses of magnetic parameters and As contents of a slag covered soil profile close to the abandoned tungsten mine in southern China, in order to discuss the feasibility of using sensitive, non-destructive, and cost-effective magnetic methods for monitoring the soil arsenic content in such arsenic pollution areas. The results indicate that arsenic sulfide entered from slags into the underlying soil and changed to iron arsenate and moveable arsenic ion.

[Clinical analysis of 382 immediately breast reconstruction after mastectomy in Beijing City, Tianjin City and Hebei Province from 2012 to 2016].

To summarize the status of immediate breast reconstruction (IBR) after mastectomy in Beijing City, Tianjin City and Hebei Province. A retrospective analysis was made on the data of 382 cases with breast cancer who were treated and followed up successfully with immediate breast reconstruction after mastectomy from January 2012 to December 2016 in Beijing City, Tianjin City and Hebei Province. Clinic data of the followed-up 382 cases (all female, age (38.

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers in a large cohort of unselected Chinese breast cancer patients.

To estimate the cumulative risk of contralateral breast cancer (CBC) in BRCA1/2 carriers in a large cohort of unselected Chinese breast cancer patients. Our study comprised 9,401 unselected Chinese breast cancer patients and BRCA1/2 germline mutations were determined in all patients. After a median follow-up of 5.

Three-Dimensional Laser-Assisted Patterning of Blue-Emissive Metal Halide Perovskite Nanocrystals inside a Glass with Switchable Photoluminescence.

The high-precision patterning of metal halide perovskites (MHPs) is of paramount importance for their device application. Here, we demonstrate the femtosecond (fs)-laser-assisted formation of three-dimensional MHP nanocrystal (NC) patterns with strong blue photoluminescence (PL) inside an oxide glass. Our strategy enables the crystallization and erasing of CsPb(Cl/Br) NCs inside a glass localized around the laser focal area through a combination of fs laser irradiation and thermal treatment processes.

Surface Reorganization on Electrochemically-Induced Zn-Ni-Co Spinel Oxides for Enhanced Oxygen Electrocatalysis.

Herein, we highlight redox-inert Zn in spinel-type oxide (Zn Ni Co O ) to synergistically optimize physical pore structure and increase the formation of active species on the catalyst surface. The presence of Zn segregation has been identified experimentally and theoretically under oxygen-evolving condition, the newly formed V -O-Co allows more suitable binding interaction between the active center Co and the oxygenated species, resulting in superior ORR performance. Moreover, a liquid flow Zn-air battery is constituted employing the structurally optimized Zn Ni Co O nanoparticles supported on N-doped carbon nanotube (ZNCO/NCNTs) as an efficient air cathode, which presents remarkable power density (109.

Strong hydrophilicity NiS/FeS heterojunctions encapsulated in N-doped carbon nanotubes for enhanced oxygen evolution reaction.

The construction of active sites with excellent water oxidation activity is of great significance in the design of OER electrocatalysts. Herein, we propose an anion regulation strategy, in which N-doped carbon nanotubes play a protective role by coating the NiFe alloy particles and two non-metallic elements S and Se are introduced to adjust the electronic structure, this can further help construct a heterogeneous surface, improve the valence state, and increase the hydrophilicity of the catalysts. The two as-prepared catalysts N-CNTs@NiS/FeS (overpotential of 330 mV to achieve 50 mA cm and Tafel slope of 51.

BRCA1 c.5470_5477del, a founder mutation in Chinese Han breast cancer patients.

The spectrum and frequency of BRCA1/2 pathogenic variants may be ethnicity-specific. Whether high-frequency founder mutations are present in Chinese women remains largely unknown. In the current study, germline pathogenic variants in the BRCA1/2 genes were determined in 9,505 unselected Chinese Han breast cancer (BC) patients by next-generation and/ or Sanger sequencing.

Effect of Trastuzumab among HER2-Positive Breast Cancer Patients that Achieved Pathologic Complete Response after Neoadjuvant Chemotherapy.

Background: We sought to investigate the incremental benefit of trastuzumab in patients with HER2-positive breast cancer who achieved a pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT).

Methods: The data of HER2-positive invasive breast cancer patients treated with NACT and achieving pCR were obtained from the institutional database. Patients were categorized according to trastuzumab administration.

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice.

Alzheimer's disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those major pathological symptoms. Jatrorrhizine (JAT), a main component of a traditional Chinese herbal, coptidis rhizome, has been shown to have neuroprotective effects and we previously showed that it is also able to clear oxygen free radicals and reduce inflammatory responses.

Quantitative Analysis of Gas Phase IR Spectra Based on Extreme Learning Machine Regression Model.

Advanced chemometric analysis is required for rapid and reliable determination of physical and/or chemical components in complex gas mixtures. Based on infrared (IR) spectroscopic/sensing techniques, we propose an advanced regression model based on the extreme learning machine (ELM) algorithm for quantitative chemometric analysis. The proposed model makes two contributions to the field of advanced chemometrics.

Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma.

The Hippo signaling pathway is highly conserved from Drosophila melanogaster to mammals and plays a crucial role in organ size control, tissue regeneration, and tumor suppression. The Yes-associated protein (YAP) is an important transcriptional co-activator that is negatively regulated by the Hippo signaling pathway. The Hippo signaling pathway is also regulated by various upstream regulators, such as cell polarity, adhesion proteins, and other signaling pathways (the Wnt/β-catenin, Notch, and MAPK pathways).

Spectrum and clinical relevance of PALB2 germline mutations in 7657 Chinese BRCA1/2-negative breast cancer patients.

Purpose: To investigate the prevalence and clinical relevance of PALB2 germline mutations in BRCA1/2-negative breast cancer patients.

Methods: The exons and intron-exon boundaries of the PALB2 gene were sequenced by multigene panel testing in a cohort of 7657 Chinese BRCA1/2-negative breast cancer patients.

Results: Of the 7657 patients, 54 (0.

Genotyping based on complete coding sequences of porcine circovirus type 3 is stable and reliable.

Porcine circovirus type 3 (PCV3) is a newly identified virus, which is associated with PDNS-like clinical signs, reproductive failure, cardiac and multiorgan inflammation. However, the genotype of PCV3 is still controversial. Here, we reconstructed the phylogenies of 194 complete coding sequences of PCV3 using five different phylogenetic methods.

Quasi-bonding driven abnormal isotropic thermal transport in intrinsically anisotropic nanostructure: a case of study of a phosphorus nanotube array.

Thermal anisotropy/isotropy is one of the fundamental characteristics of the thermal properties of a material, playing a significant role in the high-performance thermal management in micro-/nanoelectronics. It has been well documented in the literature that the symmetry of geometric structures governs the anisotropy/isotropy of thermal transport. However, the fundamental correlation and the underlying mechanism remain unclear.

Ultrasound as a replacement for physical examination in clinical staging of axillary lymph nodes in breast cancer patients.

Background: The status of axillary lymph nodes (ALNs) is one of the important factors in decision-making for breast cancer treatment. Physical examination (PE) has long been the main, or even the only, means of clinical staging for ALNs in breast cancer. However, the sensitivity and accuracy of PE remains unsatisfactory.

Surfeit 4 Contributes to the Replication of Hepatitis C Virus Using Double-Membrane Vesicles.

A number of positive-strand RNA viruses, such as hepatitis C virus (HCV) and poliovirus, use double-membrane vesicles (DMVs) as replication sites. However, the role of cellular proteins in DMV formation during virus replication is poorly understood. HCV NS4B protein induces the formation of a "membranous web" structure that provides a platform for the assembly of viral replication complexes.

RETRACTED: Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).

Enhanced photoelectrocatalytic activity of direct Z-scheme porous amorphous carbon nitride/manganese dioxide nanorod arrays.

Carbon nitride (CN) is a promising photocatalyst that can be applied in environmental remediation and energy conversion. However, the absorption range and charge separation efficiency of CN are still severely restricted for its large-scale practical applications. Herein, we demonstrate a simple thermal polymerization and electrodeposition method, followed by partial etching strategy to synthesize direct Z-scheme porous zinc oxide/amorphous carbon nitride/manganese dioxide hybrid core-shell nanorod array (denoted as P-ZnO/ACN/MnO) by encapsulating amorphous carbon nitride layers (ACN) and manganese dioxide nanosheets (MnO) on the zinc oxide nanorod arrays (denoted as ZnO).

Applicability of BaTiO/graphene oxide (GO) composite for enhanced photodegradation of methylene blue (MB) in synthetic wastewater under UV-vis irradiation.

Methylene blue (MB) is a dye pollutant commonly present in textile wastewater. We investigate and critically evaluate the applicability of BaTiO/GO composite for photodegradation of MB in synthetic wastewater under UV-vis irradiation. To enhance its performance, the BaTiO/GO composite is varied based on the BaTiO weight.

Analysis of genome-wide in cell free DNA methylation: progress and prospect.

DNA methylation is an important epigenetic marker that affects gene expression. Cell-free DNA methylation detection is a promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This review summarizes the existing literature and reviews on the detection methods based on next generation sequencing for DNA methylation.

Germline mutation in DNA-repair genes is associated with poor survival in BRCA1/2-negative breast cancer patients.

BRCA1/2 genes are the most frequently germline mutated DNA-repair genes, and the survival of BRCA1/2 carriers has been extensively explored in breast cancer. However, the prevalence of germline mutations in non-BRCA1/2 DNA-repair genes and the survival of carriers are largely unknown in a large cohort of unselected breast cancer patients. Germline mutations in 16 DNA-repair genes were determined using a multigene panel in 7657 BRCA1/2-negative breast cancer patients who were unselected for family history of cancer or age at diagnosis.