Clinical Analysis of MOG Antibody-Associated Disease Overlapped With Anti-NMDA Receptor Encephalitis: A Long-Term Retrospective Study.

To summarise the clinical characteristics, radiological features, treatments and prognosis of patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) overlapped with NMDA receptor (NMDAR) encephalitis. We retrospectively analysed patients who exhibited dual positivity for MOG antibodies and NMDAR antibodies in serum/CSF from Jan 2018 to Jun 2023. Ten patients with MOGAD and NMDAR encephalitis were enrolled.

Role of Radiomics-based Multiomics Panel in the Microenvironment and Prognosis of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent form of liver tumor, characterized by restricted therapeutic options and typically low long-term survival rates. Recently, immunotherapy has revolutionized HCC treatment, making the tumor microenvironment (TME) a research focus. Radiomics is increasingly crucial in HCC clinical decisions, offering advanced tools for TME characterization and prognosis assessment.

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer.

Background: Metastasis is the primary cause of mortality in small cell lung cancer (SCLC), with the liver being a predominant site for distal metastasis. Despite this clinical significance, mechanisms underlying the interaction between SCLC and liver microenvironment, fostering metastasis, remain unclear.

Methods: SCLC patient tissue array, bioinformatics analysis were performed to demonstrate the role of periostin (POSTN) in SCLC progression, metastasis, and prognosis.

Targeting mitochondrial function as a potential therapeutic approach for allergic asthma.

Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, excessive mucus secretion, and airway remodeling, with increasing mortality and incidence globally. The pathogenesis of allergic asthma is influenced by various factors including genetics, environment, and immune responses, making it complex and diverse. Recent studies have found that various cellular functions of mitochondria such as calcium regulation, adenosine triphosphate production, changes in redox potential, and free radical scavenging, are involved in regulating the pathogenesis of asthma.

Immunochemotherapy plus radiotherapy versus immunochemotherapy alone as first-line treatment for treatment-naïve, advanced esophageal squamous cell carcinoma (AEC-ICR-1st): A multi-center cohort study.

Immunochemotherapy is Currently the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). However, its prognosis remains unsatisfactory. We aimed to evaluate the efficacy and safety of immunochemotherapy plus radiotherapy (ICR) compared with immunochemotherapy (IC) alone as a first-line treatment for advanced ESCC.

ANGPTL4 mediated mesothelial-mesenchymal transition in pulmonary fibrosis: a potential therapeutic target.

Background: Glycolysis plays a major role in progression of idiopathic pulmonary fibrosis (IPF). Here, we aim to explore the predictive signature based on glycolysis-related genes for predicting the prognosis and identified a potential therapeutic target for IPF.

Methods: Gene expression data of bronchoalveolar lavage (BAL) cells and clinical information were downloaded from the Gene Expression Omnibus database.

Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC.

Background: Anti-programmed cell death 1 (PD-1) antibody combined with chemotherapy simultaneously is regarded as the standard treatment for patients with advanced non-small cell lung cancer (NSCLC) by current clinical guidelines. Different immune statuses induced by chemotherapy considerably affect the synergistic effects of the chemo-anti-PD-1 combination. Therefore, it is necessary to determine the optimal timing of combination treatment administration.

Anti-FDX1 Autoantibody as a Potential Biomarker for Non-Small Cell Lung Cancer Detection.

Background: Autoantibodies can be readily identified prior to biopsy and may serve as valuable biomarkers for cancer detection. Ferredoxin 1 (FDX1) is a key regulator in the process of cuproptosis and affects the prognosis of lung cancer. In this study, we investigated whether the anti-FDX1 autoantibody could serve as a novel biomarker for the detection of non-small cell lung cancer (NSCLC).

Observation of the Generalized Kerker Effect Mediated by Quasi-Bound States in the Continuum.

The generalized Kerker effect (GKE) arising from the interference of high-order multipoles has attracted more interest due to its direct correlation with various functionalities in nanophotonics. The realization of the GKE at oblique incidence is highly desired yet remains underexplored. Herein, we report the experimental observation of the GKE by leveraging quasi-bound states in the continuum (QBICs) supported by a silicon metasurface.

Gonadal transcriptome analysis of Opsariichthys bidens reveals sex-associated genes.

Opsariichthys bidens is a unique economically important freshwater fish in China. Male O. bidens grow faster than females, and male fish have attractive blue-green stripes on the body surface during the breeding period.

Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages.

Vascular calcification (VC) in type 2 diabetes (T2D) poses a serious threat to the life and health of patients. However, its pathogenesis remains unclear, resulting in a lack of effective treatment for the root cause. It is found that both intestinal Bacteroides fragilis (BF) and peripheral M2 monocytes/macrophages are significantly elevated in patients with T2D VC.

Influence of phloretin on acrolein-induced protein modification and physicochemical changes in a dairy protein model.

Acrolein (ACR) is an α,β-unsaturated aldehyde with high reactivity towards nucleophiles in proteins. In this study, a typical phenolic compound phloretin (Phl) was employed to counteract protein modification induced by ACR (1 mM) in whey protein isolate (WPI, 10 mg/mL). The addition of Phl (2 mM) significantly reduced ACR-induced surge of protein carbonyls (from 1.

Predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients through logistic regression: a model incorporating clinical characteristics, computed tomography (CT) imaging features, and tumor marker levels.

Background: Approximately 60% of Asian populations with non-small cell lung cancer (NSCLC) harbor epidermal growth factor receptor (EGFR) gene mutations, marking it as a pivotal target for genotype-directed therapies. Currently, determining EGFR mutation status relies on DNA sequencing of histological or cytological specimens. This study presents a predictive model integrating clinical parameters, computed tomography (CT) characteristics, and serum tumor markers to forecast EGFR mutation status in NSCLC patients.

Cost-Effective Synthesis of FeC Catalyst From Nanosized Zero-Valent Iron to Achieve Efficient Photothermocatalytic CO Hydrogenation to Light Olefins.

Fe-based catalysts are commonly applied in the process of Fischer-Tropsch synthesis (FTS) to olefins, with Hägg iron carbide (FeC) recognized as the primary active phase. However, iron carbonyls, the raw materials for wet chemical synthesis of FeC, are expensive and toxic, which limits large-scale preparation. Here, a cost-effective and versatile method is proposed for the synthesis of FeC nanoparticles (NPs) with nanosized zero-valent iron (abbreviated as NZVI, prepared by reducing iron salts or ball-milling iron powder) instead of iron carbonyls, achieving a cost reduction of 76.

The correlation between dental caries and dermatoglyphics: a systematic review and meta-analysis.

Here, we used a meta-analysis approach to systematically evaluate the correlation between dental caries and dermatoglyphics. To identify findings relating to the association between dental caries and dermatoglyphics, a methodical literature search was conducted in the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to August 2023. Data analysis was performed using RevMan 5.

Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-γ-induced type I interferon response network via IRF7.

The importance of CD4 T cells in cancer immunotherapy has gained increasing recognition. Particularly, a specific subset of CD4 T cells coexpressing the T helper type 1 (Th1) and Th17 markers has demonstrated remarkable antitumor potential. However, the underlying mechanisms governing the differentiation of these cells and their subsequent antitumor responses remain incompletely understood.

Advances in the enhancement of mechanical and hydrophobic properties of nanocellulose-based packaging materials: A review.

As environmental issues are hotly debated worldwide, finding suitable materials to replace petroleum-based materials as the next-generation packaging materials has become a research hotspot. Nanocellulose, as a biomass material widely available in nature, is favored for application in green packaging materials due to its environmentally friendly and bio-friendly characteristics. However, the unstable mechanical properties and strong hydrophilicity of nanocellulose limit its practical application in packaging materials.

Corrigendum: Association among biomarkers, phenotypes, and motor milestones in Chinese patients with 5q spinal muscular atrophy types 1-3.

[This corrects the article DOI: 10.3389/fneur.2024.

Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases.

Cell death is a central process for organismal health. Pyroptosis, namely pyroptotic cell death, is recognized as a critical type that disrupts membrane and triggers pro-inflammatory cytokine secretion gasdermins, providing a robust form of cytolysis. Meanwhile, along with the thorough research, a great deal of evidence has demonstrated the dual effects of pyroptosis in host defense and inflammatory diseases.

Effect of emergency medical service response time on fatality risk of freeway crashes: Bayesian random parameters spatial logistic approach.

Introduction: Emergency medical service (EMS) serves as a pivotal role in linking injured road users to hospitals via offering first aid measures and transportation. This paper aims to investigate the effect of emergency medical service (EMS) response time on the fatality risk of freeway crashes.

Methods: Crash injury severity data from Kaiyang Freeway, China in 2014 and 2015 are employed for the empirical investigation.

Octopus-inspired flocculant for oily wastewater decontamination: Hydrophilic-hydrophobic convertibility and auto-separation characters.

Unilateral hydrophobic flocculant and unsatisfactory floc separation constrained the efficacious purification of oil-containing wastewater. Illumined by the hunting behavior of mimic octopus, a biomimetic flocculant (CNSDA) with temperature-sensitive chains (color pouch) and hollow silica cores (mantle) was manufactured to derive hydrophilic-hydrophobic convertibility and auto-separation capabilities. Physical-chemical information of CNSDA was elucidated through characterization analysis.

An electrostatically spun cellulose-based self-powered mask with high efficiency air filtration and ammonia sensing.

On construction sites impacted by particulate matter and hazardous gases, portable integrated air filtration equipment with high efficiency, minimal pressure drops and ammonia (NH) alarms is critical. Triboelectric nanogenerators (TENG) present a sustainable solution by generating self-powered electricity to fulfill these requirements. In this study, we synthesized zeolitic imidazolate framework-8 (ZIF-8) in situ on the surface of titanium carbide (TiCT) to create TiCT/ZIF-8, grafted it onto cellulose diacetate via tetraethyl orthosilicate, and ultimately developed a cellulose-based nanofibrous membrane through electrospinning, combining it with a negative triboelectric material to construct a self-powered TENG-based mask.